BRAIN PHOSPHORUS-METABOLISM IN DEPRESSIVE-DISORDERS DETECTED BY P-31 MAGNETIC-RESONANCE SPECTROSCOPY
BRAIN PHOSPHORUS-METABOLISM IN DEPRESSIVE-DISORDERS DETECTED BY P-31 MAGNETIC-RESONANCE SPECTROSCOPY
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DOI：
10.1016/0165-0327(92)90099-r
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发表时间：
1992-12-01
影响因子：
6.6
通讯作者：
INUBUSHI, T
中科院分区：
文献类型：
--
作者：
KATO, T;TAKAHASHI, S;INUBUSHI, T
对22例抑郁症患者进行了脑磷代谢测定。其中10人患有DSM-III-R双相情感障碍，12人患有重度抑郁症。在双相患者中，抑郁状态下的磷酸单酯(PME)和细胞内pH值显著高于心境状态，而心境状态下的PME和细胞内pH值显著低于年龄匹配的正常人。与轻度抑郁症患者相比，重度抑郁症患者的磷酸肌酸(PCr)显著降低。这些发现提示抑郁症患者高能磷酸盐代谢、细胞内pH和膜磷脂代谢发生改变。
Brain phosphorus metabolism was measured in 22 patients with depressive disorders. Ten of them had DSM-III-R bipolar disorder, and 12 had major depression. In bipolar patients, phosphomonoester (PME) and intracellular pH were significantly increased in the depressive state than in the euthymic state, while those values in the euthymic state were significantly low as compared to age-matched normal controls. Phosphocreatine (PCr) was significantly decreased in severely depressed patients compared to mild depressives. These findings suggest that high energy phosphate metabolism, intracellular pH and membrane phospholipid metabolism are altered in depressive disorders.