Differences in IL-2 receptor levels between mycosis fungoides and cutaneous type adult T-cell leukemia/lymphoma in the early stages of the disease.
Differences in IL-2 receptor levels between mycosis fungoides and cutaneous type adult T-cell leukemia/lymphoma in the early stages of the disease.
复制标题
蕈样肉芽肿和皮肤型成人 T 细胞白血病/淋巴瘤在疾病早期阶段 IL-2 受体水平的差异。
DOI：
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发表时间：
1994
影响因子：
6.5
通讯作者：
Mitsuo Honda
中科院分区：
文献类型：
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作者：
Munashi Oishi;M. Johno;T. Ono;Mitsuo Honda
蕈样肉芽肿（MF）和皮肤型成人T细胞白血病/淋巴瘤（c-ATL）的皮肤病变有时难以区分。我们以前的研究表明，白细胞介素-2受体（IL-2 R α）的α链分泌在急性和慢性型ATL中均增强。这一发现表明c-ATL中IL-2 R α水平升高，可能与MF相区分。在这项研究中，我们报告了MF和c-ATL中IL-2 R α水平的几个观察结果。1)酶联免疫吸附试验测定的c-ATL患者（肿瘤组，17，571 +/-5，919 U/ml;非肿瘤组，4，546 +/-1，788 U/ml）的血浆IL-2 R α水平高于MF患者（肿瘤组，2，352 +/- 861 U/ml;斑块组，530 +/- 174 U/ml）。2)c-ATL皮损中IL-2 R α阳性细胞的百分比在非肿瘤组中为30.5 +/- 13.4%，在肿瘤组中为62.7 +/- 12.0%，显著高于MF、斑块组（12.7 +/- 5.9%）和肿瘤组（3.4 +/- 2.3%）。3)此外，c-ATL患者的血浆IL-2 R α水平与皮损中IL-2 R α阳性细胞数量之间存在显著相关性（r = 0.654，p < 0.0001）和MF（r = 0.537，p < 0.01）;而在MF或c-ATL患者中未观察到外周血单个核细胞中IL-2 R α水平升高。4)当通过DNA酶/逆转录/聚合酶链反应和液体杂交分析测量时，c-ATL的皮肤病变的IL-2 R α基因组RNA的水平比MF的那些在其初始阶段高得多。这些发现表明，MF或c-ATL患者血浆IL-2 R α水平升高可能与皮肤病变中的细胞IL-2 R α水平相关，因此反映了MF和c-ATL之间的差异。
Skin lesions in mycosis fungoides (MF) and cutaneous-type adult T-cell leukemia/lymphoma (c-ATL) are sometimes difficult to differentiate. Our previous investigations showed that the alpha-chain of interleukin-2 receptor (IL-2R alpha) secretion is enhanced in both acute and chronic type ATL. This finding suggested increased levels of IL-2R alpha in c-ATL that might differentiate it from MF. In this study, we report several observations on IL-2R alpha levels in MF and c-ATL. 1) Plasma levels of IL-2R alpha determined by enzyme-linked immunosorbent assay were higher in patients with c-ATL (tumor group, 17,571 +/- 5,919 U/ml; non-tumor group, 4,546 +/- 1,788 U/ml) than those of patients with MF (tumor group, 2,352 +/- 861 U/ml; plaque group, 530 +/- 174 U/ml). 2) The percentages of IL-2R alpha-positive cells in skin lesions of c-ATL were 30.5 +/- 13.4% in the non-tumor group and 62.7 +/- 12.0% in the tumor group, which were significantly higher than those of MF, plaque group (12.7 +/- 5.9%), and tumor group (3.4 +/- 2.3%). 3) Further, there was a significant correlation between plasma IL-2R alpha levels and the number of IL-2R alpha-positive cells in skin lesions in patients with c-ATL (r = 0.654, p < 0.0001) and MF (r = 0.537, p < 0.01) on an individual basis; whereas no increased IL-2R alpha levels in peripheral blood mononuclear cells were observed in patients with either MF or c-ATL. 4) Skin lesions of c-ATL had much higher levels of IL-2R alpha genomic RNA than those of MF in their initial stages when measured by DNase/reverse transcription/polymerase chain reaction and liquid hybridization analysis. These findings suggest that increased plasma IL-2R alpha levels in patients with either MF or c-ATL may be linked to cellular IL-2R alpha levels in the skin lesions, and thus reflect the difference between MF and c-ATL.
DOI：
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发表时间：
1986
期刊：
The American journal of pathology
影响因子：
--
作者：
Burke,JS;Sheibani,K;Rappaport,H
通讯作者：
Rappaport,H
与蕈样肉芽肿相关的人类嗜淋巴细胞逆转录病毒：证据表明人类 T 细胞嗜淋巴细胞病毒 II 型 (HTLV-II) 以及 HTLV-I 可能在该疾病中发挥作用。
影响因子：
20.3
作者：
Zucker-Franklin,D;Hooper,WC;Evatt,BL
通讯作者：
Evatt,BL