EFFECT OF CYCLOPHOSPHAMIDE ON RESPONSE OF CHICKENS TO A VIRULENT STRAIN OF MAREKS-DISEASE VIRUS
EFFECT OF CYCLOPHOSPHAMIDE ON RESPONSE OF CHICKENS TO A VIRULENT STRAIN OF MAREKS-DISEASE VIRUS
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DOI：
10.1128/iai.12.5.1058-1064.1975
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发表时间：
1975-01-01
影响因子：
3.1
通讯作者：
LU, YS
中科院分区：
文献类型：
--
作者：
KERMANIARAB, V;MOLL, T;LU, YS
用对马立克氏病有相对抗性的鸡品系，研究了环磷酰胺在马立克氏病发病机制中的作用。将环磷酰胺注射到新孵化的鸡体内，延迟和减少了病毒血症，并减少了马立克氏病病变的发展，直到接触马立克氏病病毒后两周。这些数据表明，一群易受病毒感染和可能的病毒转化的T细胞受到环磷酰胺的影响。
The effect of cyclophosphamide on the pathogenesis of Marek's disease was examined in a line of chickens which is relatively resistant to Marek's disease. The injection of cyclophosphamide into newly hatched chickens delayed and reduced viremia and also reduced the development of Marek's disease lesions until 2 weeks after exposure to Marek's disease virus. The data indicate that a population of T cells susceptible to infection with virus and possibly viral transformation is affected by cyclophosphamide.