HYPOTHALAMIC PARAVENTRICULAR NUCLEUS LESIONS DIFFERENTIALLY AFFECT SEROTONIN-1A (5-HT1A) AND 5-HT2 RECEPTOR AGONIST-INDUCED OXYTOCIN, PROLACTIN, AND CORTICOSTERONE RESPONSES
HYPOTHALAMIC PARAVENTRICULAR NUCLEUS LESIONS DIFFERENTIALLY AFFECT SEROTONIN-1A (5-HT1A) AND 5-HT2 RECEPTOR AGONIST-INDUCED OXYTOCIN, PROLACTIN, AND CORTICOSTERONE RESPONSES
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DOI：
10.1210/en.134.3.1127
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发表时间：
1994-03-01
期刊：
影响因子：
4.8
通讯作者：
MAKARA, GB
中科院分区：
文献类型：
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作者：
BAGDY, G;MAKARA, GB
许多受体亚型介导对5-羟色胺（5-HT）的激素反应。为了验证下丘脑室旁核（PVN）介导S-HT 1A和5-HT 2受体介导的催产素、PRL和皮质酮反应的假设，我们研究了手术PVN损伤或假手术后S-HT 1A激动剂伊沙匹龙和5-HT 2A/2C激动剂1-（2，5-二甲氧基-4-碘苯基）2-氨基丙烷（DOI）的作用。慢性插管，清醒，自由活动，雄性Wister大鼠静脉注射（1毫克/公斤）后不久（3-4天）和5周后（35-37天）的操作。在假手术大鼠，ipsapirone引起血浆PRL和皮质酮，但不是催产素浓度显着升高，而DOI增加所有三种激素的血浆浓度。短期PVN病变阻止了伊沙匹隆诱导的皮质酮和DOI诱导的催产素反应。DOI诱导的PRL和皮质酮反应在损伤后3-4天也被明显抑制，尽管仍观察到比基线值有小幅上升。伊沙匹隆诱导的PRL反应不受损伤的影响。PVN损毁5周后，观察到ipsapiron-and DOI-induced corticosterone和DOI-induced oxytocin responses部分恢复，而DOI-induced PRL responses仍然受到抑制.本研究结果表明，PVN或神经通路剂量，它介导催产素，PRL，和皮质酮反应5-HT 2受体激动剂DOI以及皮质酮，但不是PRL，对5-HT 1A受体激动剂ipsapirone的反应。长期损毁PVN后的结果表明，随着损毁时间的延长，催产素和皮质酮的反应可能部分恢复。
A number of receptor subtypes mediate hormonal responses to serotonin (5-HT). To test the hypothesis that the hypothalamic paraventricular nucleus (PVN) mediates S-HT1A and 5-HT2 receptor-mediated oxytocin, PRL, and corticosterone responses, we studied the effects of the S-HT1A agonist ipsapirone and the 5-HT2A/2C agonist 1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane (DOI) after surgical PVN lesions or sham operations. Chronically cannulated, conscious, freely moving, male Wister rats were injected iv (1 mg/kg) shortly after (3-4 days) and 5 weeks after (35-37 days) the operations. In sham-operated rats, ipsapirone caused marked elevations in plasma PRL and corticosterone, but not oxytocin concentrations, whereas DOI increased plasma concentrations of all three hormones. Short term PVN lesions prevented ipsapirone-induced corticosterone and DOI-induced oxytocin responses. DOI-induced PRL and corticosterone responses were also markedly inhibited 3-4 days after lesioning, although small rises over the baseline values were still observed. The ipsapirone-induced PRL response was unaffected by the lesioning. Five weeks after PVN lesioning, partial recoveries were observed in ipsapirone- and DOI-induced corticosterone and DOI-induced oxytocin responses, whereas DOI-induced PRL responses remained suppressed.The present findings suggest that the PVN or neural pathways dose to it mediate oxytocin, PRL, and corticosterone responses to the 5-HT2 receptor agonist DOI as well as corticosterone, but not PRL, responses to the 5-HT1A receptor agonist ipsapirone. The results after long term PVN lesioning show that the oxytocin and corticosterone responses may be partially restored with time after lesioning.