Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.
Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.
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DOI：
10.1016/j.nutres.2008.05.009
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发表时间：
2008-08
期刊：
影响因子：
--
通讯作者：
Talalay P
中科院分区：
文献类型：
--
作者：
Dinkova-Kostova AT;Fahey JW;Jenkins SN;Wehage SL;Talalay P
虽然众所周知，热量限制可以降低包括癌症在内的慢性疾病的风险，但据我们所知，体重增加在紫外线诱导的肿瘤发展中的作用尚未得到研究。鉴于世界范围内肥胖的增加，我们提出了体重增加和皮肤肿瘤发展之间是否有任何关系的问题。我们将三组，每组包括30只SKH-1无毛雌性小鼠，进行UV辐射（30 mJ/cm 2，每周两次，持续17周），并在随后的8-13周内观察肿瘤形成：第1组接受颗粒状饮食;第2组在辐射期间接受颗粒，然后转为粉末;第3组仅接受粉末。实验结束时，第1组的平均体重为32.1 ± 0.5 g，而第2组和第3组的平均体重分别为39.0 ± 1.5 g和39.5 ± 1.4 g。第3组动物在照射完成后8周肿瘤发生率达到90%，第2组动物在照射完成后13周肿瘤发生率达到90%。类似地，在辐照后8周，当组3的所有动物被安乐死时，组1、2和3的肿瘤多重性分别为0.8、1.2和3.2。因此，与食用颗粒的小鼠相比，粉末喂养的小鼠体重增加得更快，肿瘤发展得更快。考虑到世界范围内超重或肥胖的人数不断增加，我们的研究结果为倡导更健康的饮食和维持成年人恒定的体重提供了进一步的动力。
Although it is well known that caloric restriction reduces the risk of chronic diseases including cancer, the role of weight gain in the development of ultraviolet light-induced tumors has not, to our knowledge, been investigated. In view of the increase in obesity worldwide, we asked the question whether there is any relationship between body weight gain and skin tumor development. We subjected three groups, each comprising 30 SKH-1 hairless female mice, to UV radiation (30 mJ/cm2 twice weekly for 17 weeks) and observed tumor formation over the ensuing 8–13 weeks: Group 1 received pelleted diet; Group 2 received pellets during the irradiation period and was then switched to powder; and, Group 3 received powder exclusively. At the end of the experiment, the mean body weight of Group 1 was 32.1 ± 0.5 g, whereas that of Groups 2 and 3 was 39.0 ± 1.5 g and 39.5 ± 1.4 g, respectively. Tumor incidence reached 90% at 8 weeks after completion of irradiation for the animals in Group 3 and at 13 weeks for the animals in Group 2. Similarly, at 8 weeks after irradiation when all animals of Group 3 were euthanized, tumor multiplicity was 0.8, 1.2, and 3.2 for Groups 1, 2, and 3, respectively. Thus, in comparison with the mice consuming pellets, the powder-fed mice gained weight more rapidly, and developed tumors much faster. Considering the escalating numbers of individuals worldwide who are overweight or obese, our findings provide further impetus for advocating healthier diets and maintenance of constant body weight in adults.
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影响因子：
4.7
作者：
Stewart, JW;Koehler, K;Birt, DF
通讯作者：
Birt, DF
DOI：
10.1111/j.1749-6632.1947.tb30929.x
发表时间：
1947-01-01
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
TANNENBAUM, A
通讯作者：
TANNENBAUM, A
影响因子：
9.7
作者：
Dinkova-Kostova, Albena T.;Jenkins, Stephanie N.;Talalay, Paul
通讯作者：
Talalay, Paul
DOI：
10.1073/pnas.0607789103
发表时间：
2006-10-31
影响因子：
11.1
作者：
Lu, Yao-Ping;Lou, You-Rong;Conney, Allan H.
通讯作者：
Conney, Allan H.
影响因子：
4
作者：
Birt, DF;Przybyszewski, J;Liu, Y
通讯作者：
Liu, Y