Glucose and Insulin Measurements From the Oral Glucose Tolerance Test and Relationship to Muscle Mass
Glucose and Insulin Measurements From the Oral Glucose Tolerance Test and Relationship to Muscle Mass
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DOI：
10.1093/gerona/glr022
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发表时间：
2012-01-01
影响因子：
5.1
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
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作者：
Kalyani, Rita R.;Metter, E. Jeffrey;Ferrucci, Luigi
糖尿病与肌肉质量减少有关。在没有糖尿病的个体中，较高水平的葡萄糖和胰岛素对肌肉质量的影响还没有研究过。我们试图确定口服葡萄糖耐量试验(OGTT)中的胰岛素和血糖测量与非糖尿病人肌肉质量的关系。我们分析了巴尔的摩老年纵向研究(Baltimore Longitative Study of Aging，平均年龄67.3岁，范围26-95岁)中587名非糖尿病参与者的数据，他们接受了2小时的OGTT，包括每20分钟测量一次血糖和胰岛素，以及通过计算机断层扫描评估大腿中部肌肉横截面积，作为肌肉质量的替代测量。在调整了年龄、性别、种族、身高、体力活动、胰岛素抵抗的稳态模型评估后，松田指数与大腿中段肌肉横截面积(标准化体重)呈正相关和腓运动神经传导速度(均为PS
Diabetes is associated with decreased muscle mass. The effect of higher levels of glucose and insulin on muscle mass has not been studied in individuals without diabetes. We sought to determine the relationship of insulin and glucose measurements from the oral glucose tolerance test (OGTT) with muscle mass in persons without diabetes.We analyzed data from 587 participants in the Baltimore Longitudinal Study of Aging (mean age 67.3 years, range 26-95 years) without diabetes who underwent a 2-hour OGTT, including glucose and insulin measurements taken every 20 minutes and assessment of midthigh muscle cross-sectional area by computed tomography, taken as a proxy measure of muscle mass. Linear regression models and Bayesian model averaging were used to explore the independent cross-sectional association of various OGTT-derived measures and midthigh muscle cross-sectional area, independent of confounders.Individually, fasting glucose, fasting insulin, OGTT glucose (40, 60, 80, 100, and 120 minutes), OGTT insulin (20, 60, 80, 100, and 120 minutes), homeostasis model assessment of insulin resistance, integrated glucose area, and integrated insulin area were inversely associated, and the Matsuda index was positively associated, with the midthigh muscle cross-sectional area (standardized to body weight) after adjustment for age, sex, race, height, physical activity, and peroneal motor nerve conduction velocity (all ps