Overview of the Cytoskeleton from an Evolutionary Perspective
Overview of the Cytoskeleton from an Evolutionary Perspective
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DOI：
10.1101/cshperspect.a030288
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发表时间：
2018-07-01
影响因子：
7.2
通讯作者：
Goldman, Robert D.
中科院分区：
文献类型：
--
作者：
Pollard, Thomas D.;Goldman, Robert D.
这三个生命领域的生物体依靠蛋白质聚合物形成细胞骨架，帮助它们确定形状，保持机械完整性，分裂，在许多情况下，移动。真核生物具有最复杂的细胞骨架，包括三种细胞骨架聚合物——肌动蛋白丝、中间丝和微管，它们由三个运动蛋白家族（肌凝蛋白、运动蛋白和动力蛋白）作用。原核生物有与肌动蛋白和微管蛋白类似的蛋白质聚合物，但没有马达，少数细菌有一种与中间丝蛋白相关的蛋白质。
Organisms in the three domains of life depend on protein polymers to form a cytoskeleton that helps to establish their shapes, maintain their mechanical integrity, divide, and, in many cases, move. Eukaryotes have the most complex cytoskeletons, comprising three cytoskeletal polymers-actin filaments, intermediate filaments, and microtubules-acted on by three families of motor proteins (myosin, kinesin, and dynein). Prokaryotes have polymers of proteins homologous to actin and tubulin but no motors, and a few bacteria have a protein related to intermediate filament proteins.