Decreased regional cortical gray matter volume in schizophrenia.
Decreased regional cortical gray matter volume in schizophrenia.
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DOI：
10.1176/ajp.151.6.842
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发表时间：
1994-06
期刊：
影响因子：
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通讯作者：
T. Schlaepfer;G. J. Harris;A. Tien;Luon W. Peng;Seong Lee;E. Federman;Gary A. Chase;P. Barta;G. Pearlson
中科院分区：
文献类型：
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作者：
T. Schlaepfer;G. J. Harris;A. Tien;Luon W. Peng;Seong Lee;E. Federman;Gary A. Chase;P. Barta;G. Pearlson
目的：作者假设精神分裂症患者的灰质体积减少在异模态联合皮层最大。这个区域包括一个高度整合的、相互连接的系统，协调更高级的皮层功能。方法应用磁共振图像测量46例精神分裂症患者和60例年龄、性别相匹配的对照者的全脑体积和局部灰质体积。通过评估27例双相情感障碍患者来检查疾病特异性。近似背外侧前额叶皮层，下顶叶小叶，和上级颞回被选为异模态关联皮层的兴趣区域。枕骨和感觉运动区被用作比较区域，以检验区域特异性的假设。结果精神分裂症患者在指数区域的灰质体积减少，即使在总体脑体积，性别和年龄的协方差。双相情感障碍患者没有表现出异模态灰质减少。比较区域在三组之间没有差异。在对整体脑体积进行协方差分析后，各组之间的整体灰质体积没有差异。综合个别区域事后分析未发现其他灰质差异。结论：这些发现支持精神分裂症特异性异模态联合皮层灰质体积不成比例减少的理论。
OBJECTIVE The authors hypothesized that cortical gray matter volume reduction in schizophrenia is greatest in the heteromodal association cortex. This area comprises a highly integrated, reciprocally interconnected system that coordinates higher order cortical functions. METHOD Total brain and regional gray matter volumes were calculated in 46 schizophrenic patients and 60 age and sex-matched comparison subjects by using magnetic resonance images. Disease specificity was examined by assessing 27 patients with bipolar disorder. Approximations to the dorsolateral prefrontal cortex, inferior parietal lobule, and superior temporal gyrus were selected as regions of interest for the heteromodal association cortex. Occipital and sensorimotor areas were used as comparison regions to test the hypothesis for regional specificity. RESULTS Gray matter volume was reduced in schizophrenic patients in index regions even after covariance for overall brain volume, sex, and age. Bipolar disorder patients did not exhibit heteromodal gray matter reduction. Comparison regions did not differ among the three groups. Global gray matter volume was not different among groups after covariance for global brain volume. Comprehensive individual region post hoc analysis found no additional gray matter differences. CONCLUSIONS These findings support the theory of disproportionate reduction of gray matter volume in the heteromodal association cortex specific to schizophrenia.