Ethionine in the analysis of the possible separate roles of methionine and choline deficiencies in carcinogenesis.
Ethionine in the analysis of the possible separate roles of methionine and choline deficiencies in carcinogenesis.
复制标题
乙硫氨酸用于分析甲硫氨酸和胆碱缺乏在致癌过程中可能的单独作用。
DOI：
10.1007/978-1-4613-1835-4_21
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发表时间：
1986
影响因子：
--
通讯作者：
Farber,E
中科院分区：
文献类型：
--
作者：
Ghoshal,AK;Sarma,DS;Farber,E
本文简要综述了蛋氨酸的乙基类似物乙硫氨酸作为代谢探针研究蛋氨酸和胆碱在肝癌发生中可能作用的重要性。马槟榔碱诱导的肝癌发生在许多方面与其他药物的致癌作用相似，包括启动、促进和进展。然而，蛋氨酸在预防乙醇的几乎所有代谢和病理作用（包括肝癌）方面的特殊作用使乙醇处于特殊地位。根据这些观察和我们目前对胆碱缺乏在肝癌发生中的认识，我们提出胆碱和蛋氨酸在肝癌发生的启动和促进中起着独立但重叠的作用。
The importance of ethionine, the ethyl analogue of methionine, as a metabolic probe to study the possible roles of methionine and choline in liver carcinogenesis has been briefly reviewed. Ethionine-induced liver carcinogenesis is similar in many aspects, including initiation, promotion, and progression, to carcinogenesis with other agents. However, the special role of methionine in preventing virtually all metabolic and pathologic effects of ethionine, including liver cancer, places ethionine in a special position. On the basis of these observations and our current knowledge about choline deficiency in the genesis of liver cancer, we proposed that choline and methionine play separate but overlapping roles in the initiation and promotion of liver carcinogenesis.