Subscale Validation of the Neuropsychiatric Inventory Questionnaire: Comparison of Alzheimer's Disease Neuroimaging Initiative and National Alzheimer's Coordinating Center Cohorts
Subscale Validation of the Neuropsychiatric Inventory Questionnaire: Comparison of Alzheimer's Disease Neuroimaging Initiative and National Alzheimer's Coordinating Center Cohorts
复制标题
DOI：
10.1016/j.jagp.2012.10.027
复制
发表时间：
2013-07-01
影响因子：
7.2
通讯作者：
Cummings, Jeffrey L.
中科院分区：
文献类型：
--
作者：
Trzepacz, Paula T.;Saykin, Andrew;Cummings, Jeffrey L.
目的：神经精神症状在轻度认知障碍（MCI）和阿尔茨海默病（AD）中普遍存在，通常使用神经精神量表（NPI）进行测量。基于现有的探索性文献，我们报告了三个NPI问卷（NPI-Q-10）分量表的初步验证，测量临床有意义的症状群。研究方法：采用验证性非旋转主成分分析法分析了来自国家阿尔茨海默病协调中心（NACC）和阿尔茨海默病神经影像学倡议（ADNI）数据库的遗忘型MCI和AD痴呆病例的三个分量表（NPI-Q-4-额叶，NPI-Q-4-激动/攻击，NPI-Q-3-情绪）的横截面结果。结果如下：ADNI贡献了103例MCI，90例MCI转换者和112例AD痴呆病例，而NACC贡献了1,042例MCI，763例MCI转换者和3,048例AD痴呆病例。NACC的基线平均年龄较高（75.7与746），简易精神状态检查（19.5与22.4）和NPI-Q-10（5.0与43）的平均评分受损较多（第24个月），所有NPI-Q子量表均低于ADNL中位数，但NPI-Q-4-激动/攻击性和NPI-Q-3-情绪队列之间没有差异。所有尺度/子尺度上的每个项目都对主成分分析Pareto图中的方差有贡献。每个量表/子量表的因子（F）1中的所有项目在双标图上均以正方向投影（揭示一致性），而F2和F3项目显示出更多的空间分离（揭示独立性）。有显着的相似性队列的因素负荷和空间格局的项目预测，虽然因素项目的身份有所不同，特别是超过F1。结论：两个队列的结果相似，支持这些分量表的效度，值得进一步在MCI和AD患者中进行心理测量学评估，并在临床环境中进行初步应用。
Objective: Neuropsychiatric symptoms are prevalent in mild cognitive impairment (MCI) and Alzheimer disease (AD) and commonly measured using the Neuropsychiatric Inventory (NPI). Based on existing exploratory literature, we report preliminary validation of three NPI Questionnaire (NPI-Q-10) subscales that measure clinically meaningful symptom clusters. Methods: Cross-sectional results for three subscales (NPI-Q-4-Frontal, NPI-Q-4-Agitation/Aggression, NPI-Q-3-Mood) in amnestic MCI and AD dementia cases from the National Alzheimer's Coordinating Center (NACC) and Alzheimer's Disease Neuroimaging Initiative (ADNI) databases were analyzed using confirmatory unrotated principal component analysis. Results: ADNI contributed 103 MCI, 90 MCI converters, and 112 AD dementia cases, whereas NACC contributed 1,042 MCI, 763 MCI converters, and 3,048 AD dementia cases. NACC had higher baseline mean age (75.7 versus 746), and more impaired mean scores (at month 24) on Mini-Mental State Exam (19.5 versus 22.4) and NPI-Q-10 (5.0 versus 43), and all NPI-Q subscales than ADNL Medians were not different between cohorts for NPI-Q-4-Agitation/Aggression, and NPI-Q-3-Mood, however. Each item on all scales/subscales contributed variance in principal component analysis Pareto plots. All items in Factor (F) 1 for each scale/subscale projected in a positive direction on biplots (revealing coherence), whereas F2 and F3 items showed more spatial separation (revealing independence). There were remarkable similarities between cohorts for factor loadings and spatial patterns of item projections, although factor item identities varied somewhat, especially beyond F1. Conclusion: The similar pattern of results across two cohorts support validity of these subscales, which are worthy of further psychometric evaluation in MCI and AD patients and preliminary application in clinical settings.