Activity-dependent thalamocortical axon branching
Activity-dependent thalamocortical axon branching
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DOI：
10.1177/1073858408317272
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发表时间：
2008-08-01
期刊：
影响因子：
5.6
通讯作者：
Yamamoto, Nobuhiko
中科院分区：
文献类型：
--
作者：
Hayano, Yasufumi;Yamamoto, Nobuhiko
哺乳动物脑中的丘脑皮质投射涉及发育过程中分支形成的基本方面。已知TC轴突不仅以遗传定义的方式而且以活动依赖的方式形成分支。最近的证据表明，TC轴突分支产生的积极和消极的监管机构，在发展中的皮质层特异性表达。此外，使用器官型共培养物的体外研究表明，神经活动，包括射击和突触活动，控制板层特异性TC轴突分支通过改变其重塑过程中添加和消除。总之，活性依赖性机制可促进分支形成，影响分支促进和抑制因子和/或其受体分子的表达。
The thalamocortical (TC) projection in the mammalian brain involves fundamental aspects in branch formation during development. TC axons are known to form branches not only in a genetically defined but also in an activity-dependent fashion. Recent evidence indicates that TC axon branching is generated by positive and negative regulators that are expressed with laminar specificity in the developing cortex. Moreover, in vitro studies using organotypic cocultures demonstrate that neural activity, including firing and synaptic activity, controls lamina-specific TC axon branching by altering its remodeling process with addition and elimination. Taken together, activity-dependent mechanisms can contribute to branch formation, affecting expression of branch-promoting and inhibiting factors and/or their receptor molecules.