Insulin Sensitivity Following Exercise Interventions: Systematic Review and Meta-Analysis of Outcomes Among Healthy Adults.
Insulin Sensitivity Following Exercise Interventions: Systematic Review and Meta-Analysis of Outcomes Among Healthy Adults.
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DOI：
10.1177/2150131913520328
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发表时间：
2014-07
影响因子：
3.6
通讯作者：
Hafdahl AR
中科院分区：
文献类型：
--
作者：
Conn VS;Koopman RJ;Ruppar TM;Phillips LJ;Mehr DR;Hafdahl AR
虽然运动可以改善胰岛素敏感性，但运动干预对胰岛素敏感性影响的研究还没有充分的综合。这项综合性荟萃分析综合了监督运动干预的胰岛素敏感性结果。广泛的文献检索定位了测量胰岛素敏感性结局的已发表和未发表的干预研究。合格的研究测试了健康成年人的监督运动干预。对主要研究特征和结果进行编码。标准化平均差异的随机效应荟萃分析包括调节分析。对2，509名受试者（115份样本，78份报告）的数据进行了综合。两组干预后比较的总体平均效应量为0.38（95% CI [0.25，0.51]，I2 = 0%），两组前后比较的总体平均效应量为0.43（95% CI [0.30，0.56]，I2 = 52%）（治疗组的平均胰岛素敏感性高于对照组受试者）。干预后平均值为0.38与治疗受试者结束研究时平均空腹胰岛素为6.8 mU/l一致，如果对照受试者的平均空腹胰岛素为7.9 mU/l。探索性调节分析未记录干预特征或样本属性之间的不同胰岛素敏感性效应量。这项研究证明，运动是健康成年人的一种有价值的初级保健和社区健康策略，可以提高胰岛素敏感性，降低胰岛素抵抗引起的糖尿病风险。
Although exercise can improve insulin sensitivity, no adequate synthesis exists of exercise intervention studies with regard to their effect on insulin sensitivity. This comprehensive meta-analysis synthesized the insulin sensitivity outcomes of supervised exercise interventions. Extensive literature searching located published and unpublished intervention studies that measured insulin sensitivity outcomes. Eligible studies tested supervised exercise interventions among healthy adults. Primary study characteristics and results were coded. Random-effects meta-analyses of standardized mean differences included moderator analyses. Data were synthesized across 2,509 subjects (115 samples, 78 reports). The overall mean effect size for two-group post-intervention comparisons was 0.38 (95% CI [0.25, 0.51], I2 = 0%) and for two-group pre-post comparisons was 0.43 (95% CI [0.30, 0.56], I2 = 52%) (higher mean insulin sensitivity for treatment than control subjects). The post-intervention mean of 0.38 is consistent with treatment subjects ending studies with a mean fasting insulin of 6.8 mU/l if control participants’ mean fasting insulin were 7.9 mU/l. Exploratory moderator analyses did not document different insulin sensitivity effect sizes across intervention characteristics or sample attributes. This study documented that exercise is a valuable primary care and community health strategy for healthy adults to improve insulin sensitivity and lower the risk for diabetes conferred by insulin resistance.