Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit.
Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit.
复制标题
血小板耗竭对家兔 IgE 过敏反应和乙酰甘油醚磷酰胆碱输注生理变化的不同影响。
DOI：
10.1164/arrd.1981.124.4.416
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Pinckard,RN
中科院分区：
文献类型：
--
作者：
Halonen,M;Palmer,JD;Lohman,IC;McManus,LM;Pinckard,RN
乙酰甘油醚磷酸胆碱（AGEPC）的腹腔内给药可诱导家兔IgE过敏反应期间观察到的所有呼吸和循环变化。然而，先前的血小板耗竭对这两种生理反应有不同的影响。AGEPC诱导的总肺阻力增加和动态顺应性降低被先前的血小板耗竭所消除，而这些肺机械变化作为静脉内抗原激发后IgE过敏反应的一部分发生，不受血小板耗竭的影响。在AGEPC和抗原诱导反应中观察到的呼吸暂停发作不受血小板耗竭的影响，并且AGEPC反应的短暂快速浅呼吸减少至血小板完整和血小板耗竭家兔的过敏反应中观察到的特征。既往血小板耗竭对AGEPC或过敏反应的右心室高血压、心动过缓和全身性低血压影响不大。因此，AGEPC通过血小板依赖性机制诱导肺机械改变，并通过在很大程度上独立于循环血小板的机制诱导通气和循环改变。这些发现与IgE过敏反应期间AGEPC释放到血流中可能介导循环和呼吸系统改变但不介导过敏反应的肺机械改变的可能性一致。
Intravenously administered acetyl glyceryl ether phosphorylcholine (AGEPC) induced all of the respiratory and circulatory alterations observed during IgE anaphylaxis in the rabbit. Prior platelet depletion, however, had differential effects on these two physiologic responses. The AGEPC-induced increase in total pulmonary resistance and decrease in dynamic compliance were abrogated by prior platelet depletion, whereas these lung mechanical changes occurring as part of an IgE anaphylactic response after intravenous antigen challenge were unaffected by platelet depletion. The apneic episode observed in both the AGEPC and antigen-induced response was unaffected by platelet depletion, and the brief period of rapid shallow breathing of the AGEPC response was diminished to that characteristically seen in the anaphylactic response of both platelet-intact and platelet-depleted rabbits. Prior platelet depletion had little effect on right ventricular hypertension, bradycardia, and systemic hypotension of either the AGEPC or the anaphylactic responses. Thus, AGEPC induced lung mechanical alterations via platelet-dependent mechanisms and ventilatory and circulatory alterations by mechanisms largely independent of circulating platelets. These findings were consistent with the possibility that AGEPC released into the blood stream during IgE anaphylaxis may mediate the circulatory and ventilatory alterations but not the lung mechanical alterations of the anaphylactic response.