Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development.
Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development.
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DOI：
10.1155/2016/7369020
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发表时间：
2016
影响因子：
4.6
通讯作者：
Kurkowska-Jastrzębska I
中科院分区：
文献类型：
--
作者：
Bronisz E;Kurkowska-Jastrzębska I
基质金属蛋白酶9是一种蛋白水解酶，是近年来研究较多的生物标志物之一。它可能被用作中风、心脏病、肿瘤、多发性硬化症和癫痫中神经元损伤的生物标志物。在癫痫中，MMP-9被认为在癫痫灶形成和刺激癫痫发作中发挥作用。在动物模型和临床研究中均观察到癫痫灶中MMP-9活性的增加。例如，通过突触的重塑，MMP-9有助于癫痫灶的形成。它对血脑屏障成分的蛋白水解作用和趋化过程的激活促进了炎症细胞的积累并诱发癫痫发作。此外，MMP-9对谷氨酸能传递的改变与癫痫发作有关。在这篇综述中，我们将尝试总结以往关于MMP-9与癫痫的关系的研究结果。我们将讨论其作用机制，并介绍在动物模型和临床研究中发现的结果。我们还将提供关于MMP-9水平的各种研究结果的比较，在其可能用作癫痫活动的生物标志物的背景下。
Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic focus formation and in the stimulation of seizures. The increase of MMP-9 activity in the epileptic focus was observed both in animal models and in clinical studies. MMP-9 contributes to formation of epileptic focus, for example, by remodeling of synapses. Its proteolytic action on the elements of blood-brain barrier and activation of chemotactic processes facilitates accumulation of inflammatory cells and induces seizures. Also modification of glutamatergic transmission by MMP-9 is associated with seizures. In this review we will try to recapitulate the results of previous studies about MMP-9 in terms of its association with epilepsy. We will discuss the mechanisms of its actions and present the results revealed in animal models and clinical studies. We will also provide a comparison of the results of various studies on MMP-9 levels in the context of its possible use as a biomarker of the activity of epilepsy.
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影响因子：
20.3
作者：
Deem, TL;Cook-Mills, JM
通讯作者：
Cook-Mills, JM
影响因子：
4.1
作者：
Curia G;Lucchi C;Vinet J;Gualtieri F;Marinelli C;Torsello A;Costantino L;Biagini G
通讯作者：
Biagini G
DOI：
10.1523/jneurosci.0141-11.2011
发表时间：
2011-08-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Court FA;Zambroni D;Pavoni E;Colombelli C;Baragli C;Figlia G;Sorokin L;Ching W;Salzer JL;Wrabetz L;Feltri ML
通讯作者：
Feltri ML
影响因子：
5.6
作者：
Engel, J
通讯作者：
Engel, J
影响因子：
5.3
作者：
Asahi, M;Wang, XY;Lo, EH
通讯作者：
Lo, EH