Stability-indicating high-performance liquid chromatographic analysis of trimethoprim in pharmaceuticals.
Stability-indicating high-performance liquid chromatographic analysis of trimethoprim in pharmaceuticals.
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药物中甲氧苄啶的稳定性指示高效液相色谱分析。
DOI：
10.1016/s0021-9673(01)94565-0
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Breytenbach
中科院分区：
文献类型：
--
作者：
J. Bergh;J. Breytenbach
甲氧苄啶(I)的降解是通过在酸性介质中回流加热原料或将甲氧苄啶悬浮液在不同的缓冲溶液中暴露在直射阳光下实现的。产物II-VI主要由核磁共振和质谱学鉴定。(化合物II和V的纯样品由英国达特福德的惠康基金会提供)
The degradation of trimethoprim (I) was achieved by heating the raw material under reflux in acidic media or by exposing suspensions of trimethoprim in various buffer solutions to direct sunlight. The products II-VI were identified mainly by NMR and mass spectrometry.(Pure samples of compounds II and V were supplied by the Wellcome Foundation, Dartford, UK)