Taking the long view on metabolism.
Taking the long view on metabolism.
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从长远的角度看待新陈代谢。
DOI：
10.1126/science.abl4537
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Anderson,RozalynM
中科院分区：
文献类型：
--
作者：
Rhoads,TimothyW;Anderson,RozalynM
新陈代谢不仅仅是能量--身体如何处理营养燃料并将其转化为可用的能量货币。代谢还包括合成、修饰和交换用于细胞功能的所有方面的构件，并充当细胞活性的传感器和调节器，其中代谢途径内的单个部分影响细胞反应。每天需要大量的能量来维持生命;身体活动的能量需求叠加在一个巨大的综合机器上。代谢状态与无数疾病和紊乱有关，包括那些随着年龄增长而最普遍的疾病（-）。在本期的第808页，Pontzeret等人分析了来自地球仪29个国家的6400多名男性和女性的能量消耗，年龄在8天到95岁之间，并显示了发育和衰老过程中不同的代谢阶段。
Metabolism is not just about energy—how the body handles nutrient fuel and converts it to useable energetic currency. Metabolism also encompasses synthesis, modification, and exchange of the building blocks for all aspects of cellular function and acts as a sensor and regulator of cellular activities, in which individual moieties within metabolic pathways influence cellular responses. A substantial amount of the energy taken in each day is required to simply sustain life; the energetic demands of physical activity are superimposed on a vastly integrated machinery. Metabolic status has been linked to innumerable diseases and disorders, including those most prevalent with age (–). On page 808 of this issue, Pontzeret al.analyze energy expenditure in more than 6400 males and females from 29 countries across the globe, aged between 8 days and 95 years, and show distinct metabolic phases during development and aging.