Cultivating Healthy Connections: Exploring and Engineering the Microbial Flow That Shapes Microbiomes.
Cultivating Healthy Connections: Exploring and Engineering the Microbial Flow That Shapes Microbiomes.
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DOI：
10.1128/msystems.00863-21
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发表时间：
2021-10-26
期刊：
影响因子：
6.4
通讯作者：
Wiles TJ
中科院分区：
文献类型：
--
作者：
Wiles TJ
在过去的十年里，我们对微生物世界的看法发生了根本性的转变。在20世纪的大部分时间里，医学微生物学研究的重点是了解致病病原体的毒性。最近，DNA测序方法的进步揭示了与我们的身体和周围环境有关的更广泛的微观野生动物多样性，以及它们在支持我们的健康方面发挥的意想不到的作用。我们对微生物世界的不断扩展的看法现在正在推动治疗干预，这些干预不仅基于消除邪恶的病原体，而且基于培养有益的微生物群。在这篇评论中，我考虑了我们历史上基于病原体的宿主-微生物相互作用的观点如何限制了工程微生物组的新和替代策略的范围。我认为，认识到连接微生物组的正在进行的微生物传播的治疗潜力，可以为培养健康的宿主-微生物关系提供尚未探索的机会。
Our view of the microbial world has undergone a radical transformation over the past decade. For most of the 20th century, medical microbiological research was focused on understanding the virulent nature of disease-causing pathogens. More recently, advances in DNA sequencing methodologies have exposed a wider diversity of microscopic wildlife that associate with our bodies and the environments around us, and the unexpected roles they play in supporting our health. Our expanding view of the microbial world is now motivating therapeutic interventions that are based not just on the elimination of nefarious pathogens but the nurturing of beneficial microbiomes. In this Commentary, I consider how our historically pathogen-based view of host-microbe interactions may be limiting the scope of new and alternative strategies for engineering microbiomes. I suggest that recognizing the therapeutic potential of the ongoing microbial transmission that connects microbiomes could illuminate unexplored opportunities for cultivating healthy host-microbe relationships.