Epidemiology and Cytokine Levels among Children with Nosocomial Multidrug-Resistant Acinetobacter baumannii Complex in a Tertiary Hospital of Eastern China.
Epidemiology and Cytokine Levels among Children with Nosocomial Multidrug-Resistant Acinetobacter baumannii Complex in a Tertiary Hospital of Eastern China.
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DOI：
10.1371/journal.pone.0161690
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Zhou M
中科院分区：
文献类型：
--
作者：
Fang C;Chen X;Zhou M
本研究旨在评估中国东部某三级医院院内多重耐药鲍曼不动杆菌复合体（MDR ABC）患儿的特征。 MDR ABC 对公众健康构成严重威胁。然而，缺乏有关儿童院内 MDR ABC 的信息。本研究回顾性分析了华东地区某三甲医院2011年1月1日至2014年12月31日期间的病例（不包括门诊患者）。从各种样本中收集到总共 377 个非重复的院内 ABC 分离株，其中包括 200 个（53.1%）MDR ABC 分离株。此外，200 株 MDR ABC 分离株中的 158 株是从重症监护室（ICU；MDR 构成比，62.5%）收集的，而 200 株 MDR ABC 分离株中，98 株是从 1 岁以上儿童中收集的（MDR 构成比，62.8%）。多因素logistic分析显示，入住外科重症监护病房（SICU）、住院时间延长、手术干预和机械通气是院内ABC儿童获得MDR的独立危险因素。院内MDR ABC患儿白细胞介素（IL）-6水平显着低于院内非MDR ABC患儿。院内 MDR ABC 感染是儿科患者的一个严重问题。在 SICU 中，延长住院时间、手术干预和机械通气会增加院内 MDR ABC 的风险。 IL-6 可能与儿童院内 MDR ABC 的发生有关。
The present study was aimed at assessing the characteristics of children with nosocomial multidrug-resistant Acinetobacter baumannii complex (MDR ABC) in a tertiary hospital of eastern China. MDR ABC poses a serious threat to public health. However, information on nosocomial MDR ABC in children is lacking. This study retrospectively reviewed the cases in a tertiary hospital of eastern China between January 1, 2011, and December 31, 2014 (excluding outpatients). A total of 377 non-duplicated nosocomial ABC isolates were collected from various samples including 200 (53.1%) MDR ABC isolates. Moreover, 158 of the 200 MDR ABC isolates were collected from intensive care units (ICUs; MDR constituent ratios, 62.5%), while 98 of the 200 MDR ABC isolates were collected from children older than 1 year (MDR constituent ratios, 62.8%). Multivariate logistic analysis revealed that being in the surgical intensive care unit (SICU), prolonged hospital stay, surgical intervention, and mechanical ventilation were independent risk factors for MDR acquisition among children with nosocomial ABC. The interleukin (IL)-6 level of children with nosocomial MDR ABC was significantly lower than that of the children with nosocomial non-MDR ABC. Nosocomial MDR ABC infection is a serious concern in pediatric patients. Being in the SICU, prolonged hospital stay, surgical intervention, and mechanical ventilation increased the risk of nosocomial MDR ABC. IL-6 might be involved in developing nosocomial MDR ABC among children.
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