Effects of retrovirus protein on the feline one-way mixed leukocyte reaction.
Effects of retrovirus protein on the feline one-way mixed leukocyte reaction.
复制标题
逆转录病毒蛋白对猫单向混合白细胞反应的影响。
DOI：
10.1099/0022-1317-64-4-957
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Olsen,RG
中科院分区：
文献类型：
--
作者：
Stiff,MI;Olsen,RG
本研究的目的是评价猫逆转录病毒蛋白对猫淋巴细胞识别同种异体细胞的混合白细胞反应（MLR）的影响，使用u. v. -灭活猫白血病病毒（FeLV）和非致病内源性猫病毒（RD-114）。20微克紫外线将来自每种病毒的灭活病毒蛋白加入到混合的白细胞培养物中。FeLV诱导了MLR的显著抑制（P< 0.005），而RD-114未发现显著抑制。由于猫白血病感染与免疫抑制有关，逆转录病毒蛋白质可能会干扰免疫活性细胞的反应，当它们面对一个改变的宿主细胞。
The objective of this study was to evaluate the effects of feline retrovirus protein on cat lymphocyte recognition of allogeneic cells in the mixed leukocyte reaction (MLR), using u.v.-inactivated feline leukaemia virus (FeLV) and a non-disease-producing endogenous cat virus (RD-114). Twenty micrograms of u.v.-inactivated virus protein from each virus were added to mixed leukocyte cultures. FeLV induced significant suppression of the MLR (P< 0.005) whereas no significant suppression was found using RD-114. Since feline leukaemia infection is associated with immunosuppression, the retrovirus proteins may be interfering with the response of immunocompetent cells when they are confronted with an altered host cell.