Serum levels of ADAM12‐S: possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis
Serum levels of ADAM12‐S: possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis
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DOI：
10.1111/j.1468-3083.2012.04558.x
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发表时间：
2013-06
影响因子：
9.2
通讯作者：
T. Taniguchi;Y. Asano;K. Akamata;N. Aozasa;S. Noda;T. Takahashi;Y. Ichimura;T. Toyama;H. Sumida;Y. Kuwano;K. Yanaba;Y. Tada;M. Sugaya;T. Kadono;S. Sato
中科院分区：
文献类型：
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作者：
T. Taniguchi;Y. Asano;K. Akamata;N. Aozasa;S. Noda;T. Takahashi;Y. Ichimura;T. Toyama;H. Sumida;Y. Kuwano;K. Yanaba;Y. Tada;M. Sugaya;T. Kadono;S. Sato
背景去整合素和金属蛋白酶（adintegrin and metalloprotease，ADAM）12是金属蛋白酶型亚当斯的一种，具有细胞外金属蛋白酶和细胞结合功能。ADAM 12以两种替代形式表达，例如膜锚定形式（ADAM 12-L）和短分泌形式（ADAM 12-S）。
Background A disintegrin and metalloprotease (ADAM) 12 is one of the metalloproteinase‐type ADAMs and possesses extracellular metalloprotease and cell‐binding functions. ADAM12 is expressed in two alternative forms, such as a membrane‐anchored form (ADAM12‐L) and a short secreted form (ADAM12‐S).