Mandibular Reconstruction by Using a Liquid Nitrogen-Treated Autograft in a Dog with an Oral Tumor
Mandibular Reconstruction by Using a Liquid Nitrogen-Treated Autograft in a Dog with an Oral Tumor
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DOI：
10.5326/jaaha-ms-6339
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发表时间：
2017-05-01
影响因子：
1.3
通讯作者：
Uzuka, Yuji
中科院分区：
文献类型：
--
作者：
Okamura, Yasuhiko;Heishima, Kazuki;Uzuka, Yuji
一只 10 岁未绝育的雌性德国牧羊犬，其下颌出现大的周围牙源性纤维瘤和恶性黑色素瘤。通过单侧半颌头侧次全切除术切除肿瘤。下颌骨被移除后，术中通过液氮冷冻使其失活。随后它被重新植入。新的骨组织在冷冻骨和宿主骨之间的间隙中形成。再生骨含有骨细胞、成骨细胞和血管。狗的外观得以保留。狗有正常的咀嚼能力。重建手术后159天，恶性黑色素瘤在左侧犬齿吻端复发。随后进行了半下颌骨次全切除术。这是首例报道使用液氮处理的自体移植物对患有口腔肿瘤的狗进行下颌骨重建的病例。
A 10 yr old intact female German shepherd dog presented with a large peripheral odontogenic fibroma and malignant melanoma on her lower jaw. The tumor was resected with a unilateral subtotal rostral hemimandibulectomy. After the mandible was removed, it was devitalized intraoperatively by freezing it in liquid nitrogen. It was subsequently reimplanted. New bone tissue formed in the gap between the frozen bone and the host bone. The regenerated bone contained osteocytes, osteoblasts, and blood vessels. The cosmetic appearance of the dog was preserved. The dog had normal mastication. The malignant melanoma recurred rostral of the left canine tooth at 159 days after the reconstruction surgery. A subtotal hemimandibulectomy was consequently performed. This is the first reported case of mandibular reconstruction using a liquid nitrogen-treated autograft in a dog with oral tumors.