Quadruplex DNA crystal structures and drug design
Quadruplex DNA crystal structures and drug design
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DOI：
10.1016/j.biochi.2008.03.003
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发表时间：
2008-08-01
期刊：
影响因子：
3.9
通讯作者：
Parkinson, Gary N.
中科院分区：
文献类型：
--
作者：
Neidle, Stephen;Parkinson, Gary N.
到目前为止，对G-四链核酸的结晶学研究已经产生了一小群结构。这里描述了它们的形态和详细的构象特征，强调了G-四分体核心的稳定性和环的灵活性，特别是在配体结合时。在端粒和非端粒四链DNA的可药性的背景下，讨论了药物设计的含义。(C)2008年爱思唯尔·马森公司。版权所有。
Crystallographic studies of G-quadruplex nucleic acids have resulted in a small group of structures to date. Their morphological and detailed conformational features are described here, emphasizing the stability of the G-tetrad core and the flexibility of loops, especially upon ligand binding. Implications for drug design are discussed, in the context of the druggability of both telomeric and non-telomeric quadruplex DNAs. (C) 2008 Elsevier Masson SAS. All rights reserved.