Manganese oxide nano-platforms in cancer therapy: Recent advances on the development of synergistic strategies targeting the tumor microenvironment
Manganese oxide nano-platforms in cancer therapy: Recent advances on the development of synergistic strategies targeting the tumor microenvironment
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DOI：
10.1016/j.apmt.2022.101628
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发表时间：
2022-08-31
影响因子：
8.3
通讯作者：
Hueso, Jose L.
中科院分区：
文献类型：
--
作者：
Bonet-Aleta, Javier;Calzada-Funes, Javier;Hueso, Jose L.
使用无机纳米材料来解决和利用肿瘤微环境（TME）的内在化学性质已成为癌症治疗中一种有前途的策略。氧化锰纳米颗粒（MnxOy）在氧化还原性质和对TME方案的特异性方面具有独特的优势：低O2浓度、温和的酸性pH和高氧化应激;环境条件通常会导致癌症治疗效果降低。MnxOy为基础的纳米平台最近表现出令人兴奋的性能，作为无机纳米催化剂下TME的约束。或者，Mn-纳米催化剂还显示出与其他活性共佐剂元素（药物、酶或纳米材料）组合的协同抗癌反应。这篇综述的目的是提供新的见解锰基纳米材料应用于癌症治疗的主要功能。我们分析了它在缺氧情况下作为氧供应者的能力，它诱导谷胱甘肽（GSH）选择性耗尽以最大化细胞应激的作用，或它通过葡萄糖氧化促进饥饿治疗的能力。我们的目标是提供这些关键过程背后的操作机制的深刻见解，并强调Mn基纳米颗粒在这一发展中领域的多功能性和催化丰富性。我们还提供了一个一般和全面的分析锰的命运时，通过细胞内水平贩运。
The use of inorganic nanomaterials to tackle and exploit the intrinsic chemical nature of the tumor microenvironment (TME) has emerged as a promising strategy in cancer therapy. Manganese oxide nanoparticles (MnxOy) offer unique advantages in terms of redox properties and specificity towards the TME scenario: low O2 con-centrations, mildly acidic pH and high oxidative stress; environmental conditions that often lead to a reduction in the efficacy of cancer treatments. MnxOy-based nanoplatforms have recently demonstrated exciting properties as inorganic nanocatalysts to operate under TME constraints. Alternatively, Mn-nanocatalysts have also displayed synergistic anticancer response in combination with other active co-adjuvant elements (drugs, enzymes or nanomaterials). The aim of this review is to provide new insights on the main functionalities of Mn-based nanomaterials applied to cancer therapy. We analyze its capacity as oxygen supplier in hypoxic scenarios, its role to induce the selective depletion of glutathione (GSH) to maximize cell stress or its capacity to promote starvation therapy via glucose oxidation. We aim at providing an insightful view of the operating mechanisms behind each of these critical processes and highlight the versatility and catalytic richness of Mn-based nano -particles in this developing field. We also provide a general and comprehensive analysis of the Mn fate when trafficking through the intracellular levels.