The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and cats
The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and cats
复制标题
DOI：
10.1292/jvms.65.1057
复制
发表时间：
2003-10-01
影响因子：
1.2
通讯作者：
Ishikawa, Y
中科院分区：
文献类型：
--
作者：
Uechi, M;Matsuoka, M;Ishikawa, Y
托拉塞米是一种新的循环利尿剂，结合了呋塞米和螺内酯的作用。目前还没有关于托拉塞米对猫和狗的影响的报道。本研究比较了速尿和托拉塞米对猫和狗的利尿作用。患有压力过载心脏肥厚的猫给予口服安慰剂、托拉塞米0.3 mg/kg或呋塞米1 mg/kg或3 mg/kg。对照组和二尖瓣反流犬分别口服安慰剂、托拉塞米0.2 mg/kg和呋塞米2 mg/kg，疗程7 d。在基线和每次给药后1、2、3、4、5、6、8、12和24小时采集尿样。测定尿量、尿Na+、K+。速尿和托拉塞米给药后1小时尿量均增加。速尿引起猫和狗尿量的剂量依赖性增加，在2-3小时达到峰值。在猫和狗身上，速尿的利尿作用在给药后6小时消失，托拉塞米的利尿作用在给药后2-4小时达到峰值并持续12小时。在MR犬中，托拉塞米7天显著减少尿钾排泄。托拉塞米组血浆醛固酮升高，而速尿组无变化。综上所述，约1/10浓度的托拉塞米对猫和狗的利尿作用与速尿一样有效，且利尿作用更长。这些数据表明，托拉塞米可用于治疗猫和狗的充血性心力衰竭或水肿。
Torasemide is a new loop diuretic that combines the effects of furosemide and spironolactone. There are no reports on the effects of torasemide in cats and dogs. This study compared the diuretic effects of furosemide and torasemide in cats and dogs. Cats with pressure overload cardiac hypertrophy were given oral placebo, torasemide 0.3 mg/kg, or furosemide 1 mg/kg or 3 mg/kg. Control and mitral regurgitation dogs were given oral placebo, torasemide 0.2 mg/kg, and furosemide 2 mg/kg for 7 days. Urine samples were obtained at baseline and 1, 2, 3, 4, 5, 6, 8, 12, and 24 hr after each drug dose. Urine volume and urine Na+ and K+ were measured. Both furosemide and torasemide increased urine volume I hr after administration. Furosemide caused a dose-dependent increase in urine volume that peaked at 2-3 hr in cats and dogs. The diuretic effect of furosemide disappeared 6 hr after administration, while that of torasemide peaked 2-4 hr after administration and persisted for 12 hr in cats and dogs. In MR dogs, torasemide for 7 days significantly decreased urine potassium excretion. Plasma aldosterone increased with torasemide, whereas there was no change with furosemide. In conclusion, about 1/10 concentration of torasemide was as potent as furosemide and had a longer diuretic effect in cats and dogs. These data suggest that torasemide is useful for treating congestive heart failure or edema in cats and dogs.