Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231
Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231
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DOI：
10.3892/ijo_00000549
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发表时间：
2010-03-01
影响因子：
5.2
通讯作者：
Chenais, Benoit
中科院分区：
文献类型：
--
作者：
Blanckaert, Vincent;Ulmann, Lionel;Chenais, Benoit
乳腺癌是工业化国家女性最常见的癌症。饮食差异等环境因素可能对癌症的发生有重要影响。在这些因素中，n-3 多不饱和脂肪酸，如二十二碳六烯酸 (DHA)，是预防乳腺癌的良好候选者。在这里，我们研究了 DHA 对人乳腺癌细胞系 MDA-MB-231 的影响，结果表明 DHA 的掺入 i) 具有抗增殖作用，ii) 通过短暂增加 caspase-3 活性和促进核浓缩来诱导细胞凋亡，iii) 降低 MDA-MB-231 细胞的侵袭潜力。总而言之，DHA 可能具有减缓肿瘤细胞增殖并最大程度降低其转移潜力的有益作用。
Breast cancer is the most common cancer in women in industrialized countries. Environmental factors, such as differences in diet are likely to have an important influence on cancer emergence. Among these factors, n-3 polyunsaturated-fatty acids, such as docosahexaenoic acid (DHA), are good candidates for preventing breast cancer. Here we investigate the effect of DHA on the human breast cancer cell line MDA-MB-231 and show that DHA incorporation i) has an anti-proliferative effect, ii) induces apoptosis via a transient increase in caspase-3 activity and the promotion of nuclear condensation, and iii) reduces the invasive potential of MDA-MB-231 cells. To conclude, DHA may have beneficial effects as a result of slowing the proliferation of tumor cells, and minimizing their metastatic potential.