Neural connections of the anterior hypothalamus and agonistic behavior in golden hamsters
Neural connections of the anterior hypothalamus and agonistic behavior in golden hamsters
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DOI：
10.1159/000006642
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发表时间：
2000-02-01
影响因子：
1.7
通讯作者：
Ferris, CF
中科院分区：
文献类型：
--
作者：
Delville, Y;De Vries, GJ;Ferris, CF
在雄性金仓鼠中，攻击性攻击是由下丘脑前部水平的精氨酸加压素和5-羟色胺之间的相互作用调节的。目前的研究进行了研究这种相互作用的神经网络。用逆行和顺行追踪法观察了成年雄性仓鼠下丘脑前部的神经联系。几个边缘区被发现包含这两种类型的跟踪表明与前下丘脑的相互联系。通过比较两组动物的神经元活动（通过量化c-fos免疫标记进行检查）来测试它们与攻击完成相关的功能意义。实验动物在攻击入侵者后被处死。对照组动物在暴露于带有入侵者气味的木板后被处死，这些气味引起与攻击性攻击相关的行为，但没有完成。在实验动物的杏仁内侧核、下丘脑腹外侧区、终纹床核和中脑中央灰质背外侧部，Fos免疫反应性密度增加。这些数据表明，这些区域整合在一个以下丘脑前部为中心的神经网络中，并参与攻击性攻击的完成。最后，c-fos免疫反应结合标记的5-羟色胺和加压素神经元，以确定亚群特别是与进攻性侵略。在视上核的环状核和内侧部的加压素神经元显示增加的神经元活动的战士，支持他们的作用，在控制进攻性的侵略，版权（C）2000 S。Karger AG，巴塞尔。
In male golden hamsters, offensive aggression is regulated by an interaction between arginine-vasopressin and serotonin at the level of the anterior hypothalamus. The present studies were conducted to study a neural network underlying this interaction. The connections of the anterior hypothalamus were examined by retrograde and anterograde tracing in adult male hamsters. Several limbic areas were found to contain both types of tracing suggesting reciprocal connections with the anterior hypothalamus. Their functional significance relating to the consummation of aggression was tested by comparing neuronal activity (examined through quantification of c-fos-immunolabeling) in two groups of animals. Experimental animals were sacrificed after attacking an intruder. Control animals were sacrificed after exposure to a woodblock carrying the odor of an intruder that elicited behaviors related to offensive aggression without its consummation. An increased density of Fos-immunoreactivity was found in experimental animals within the medial amygdaloid nucleus, ventrolateral hypothalamus, bed nucleus of the stria terminalis and dorsolateral part of the midbrain central gray. These data suggest that these areas are integrated in a neural network centered on the anterior hypothalamus and involved in the consummation of offensive aggression. Finally, c-fos-immunoreactivity was combined with labeling of serotonin and vasopressin neurons to identify sub-populations particularly associated with offensive aggression. Vasopressin neurons in the nucleus circularis and medial division of the supraoptic nucleus showed increased neuronal activity in the fighters, supporting their role in the control of offensive aggression, Copyright (C) 2000 S. Karger AG, Basel.