Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner
Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner
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基于双包层光纤组合器的荧光和光学相干断层扫描探头组合的血管内动脉粥样硬化成像
DOI：
10.1117/1.jbo.17.7.070501
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发表时间：
2012-07-01
影响因子：
3.5
通讯作者：
Chen, Zhongping
中科院分区：
文献类型：
--
作者：
Liang, Shanshan;Saidi, Arya;Chen, Zhongping
我们研制了一种基于双包层光纤（DCF）合束器的多模荧光和光学相干层析成像探头。探头由DCF组合器、自聚焦透镜和远端的微电机组成。基于该组合探头，研制了扫频光源光学相干断层成像和荧光强度成像一体化系统，用于动脉粥样硬化的早期诊断。该系统能够进行实时数据采集、处理和图像显示。对于荧光成像，对动脉粥样硬化的炎症和用膜联蛋白V缀合的Cy5.5形成的坏死核心进行成像。新西兰白色兔动脉的离体成像证明了组合系统的能力。(C)2012年，美国光电仪器工程师学会（SPIE）。[DOI：10.1117/1.JBO.17.7.070501
We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.7.070501