Molecular Mechanisms Involved in Schwann Cell Plasticity.
Molecular Mechanisms Involved in Schwann Cell Plasticity.
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DOI：
10.3389/fnmol.2017.00038
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发表时间：
2017
影响因子：
4.8
通讯作者：
Franzen R
中科院分区：
文献类型：
--
作者：
Boerboom A;Dion V;Chariot A;Franzen R
雪旺细胞不可思议的可塑性是神经损伤或脱髓鞘神经病的重要标志。损伤后，雪旺细胞先去分化后再分化，促进神经再生和功能完全恢复。本文综述并讨论了髓鞘形成的负调控以及神经损伤后早期雪旺细胞重编程以支持修复的分子机制。调控SC再生特性的信号通路和分子成分研究取得了重大进展。这些包括转录调控因子，例如c-Jun或Notch， MAPK和Nrg1/ErbB2/3通路。这篇全面的综述以一些针对控制雪旺细胞可塑性的因子的治疗应用结束，并强调需要仔细调节和平衡这种驱动神经修复的能力。
Schwann cell incredible plasticity is a hallmark of the utmost importance following nerve damage or in demyelinating neuropathies. After injury, Schwann cells undergo dedifferentiation before redifferentiating to promote nerve regeneration and complete functional recovery. This review updates and discusses the molecular mechanisms involved in the negative regulation of myelination as well as in the reprogramming of Schwann cells taking place early following nerve lesion to support repair. Significant advance has been made on signaling pathways and molecular components that regulate SC regenerative properties. These include for instance transcriptional regulators such as c-Jun or Notch, the MAPK and the Nrg1/ErbB2/3 pathways. This comprehensive overview ends with some therapeutical applications targeting factors that control Schwann cell plasticity and highlights the need to carefully modulate and balance this capacity to drive nerve repair.