Comparison of the telephone-Montreal Cognitive Assessment (T-MoCA) and Telephone Interview for Cognitive Status (TICS) as screening tests for early Alzheimer's disease.
Comparison of the telephone-Montreal Cognitive Assessment (T-MoCA) and Telephone Interview for Cognitive Status (TICS) as screening tests for early Alzheimer's disease.
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蒙特利尔电话认知评估 (T-MoCA) 和认知状态电话访谈 (TICS) 作为早期阿尔茨海默病筛查测试的比较。
DOI：
10.1002/alz.13039
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Salmon,DavidP
中科院分区：
文献类型：
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作者：
Chappelle,SheridanD;Gigliotti,Christina;Léger,GabrielC;Peavy,GuerryM;Jacobs,DianeM;Banks,SarahJ;Little,EmilyA;Galasko,Douglas;Salmon,DavidP
随着老年人群中阿尔茨海默病（AD）患病率的预期上升以及新的潜在治疗方案的出现，远程筛查与AD相关的认知障碍变得越来越重要。方法对通过面对面临床评估独立分类为认知正常（CN, n= 167）、轻度认知障碍（MCI, n= 25）或痴呆（n= 23）的参与者进行认知状态电话访谈（TICS）和蒙特利尔认知评估新电话适应（T - MoCA）。检测脑脊液AD生物标志物（n= 79）。结果TICS与T‐MoCA高度相关（r= 0.787， P< 0.001）；两组之间存在差异（CN<MCI<痴呆；TICS:F[2212] = 156.66， P< 0.001; T‐MoCA:F[2210] = 143.72， P< 0.001）；两组均能有效检测认知障碍（受试者工作特征曲线下面积：TICS = 0.889, T‐MoCA = 0.902）；两组均与AD复合生物标志物（tau/淀粉样蛋白β 1‐42，TICS:r= - 0.372， P= 0.001; T‐MoCA:r= - 0.480， P< 0.001）呈负相关。tic和T - MoCA对于远程检测老年人AD相关认知障碍是有效的。测试之间的强相关性为较新的T - MoCA提供了结构效度。蒙特利尔认知评估（T - MoCA）的电话适应性结构效度是针对认知状态电话访谈（TICS）新建立的。通过远程给药，tic和T - MoCA可以有效检测认知障碍。两项测试均与复合脑脊液阿尔茨海默病（AD）生物标志物（tau/淀粉样蛋白1‐42）负相关。
IntroductionRemote screening for cognitive impairment associated with Alzheimer's disease (AD) has grown in importance with the expected rise in prevalence of AD in an aging population and with new potential treatment options.MethodsThe Telephone Interview for Cognitive Status (TICS) and new telephone adaptation of the Montreal Cognitive Assessment (T‐MoCA) were administered to participants independently classified through in‐person clinical evaluation as cognitively normal (CN;n= 167), mild cognitive impairment (MCI;n= 25), or dementia (n= 23). Cerebrospinal fluid AD biomarkers were measured (n= 79).ResultsTICS and T‐MoCA were highly correlated (r= 0.787;P< 0.001): groups differed on both (CN<MCI<dementia; TICS:F[2212] = 156.66;P< 0.001; T‐MoCA:F[2210] = 143.72;P< 0.001), both effectively detected cognitive impairment (receiver operating characteristic area under the curve: TICS = 0.889; T‐MoCA = 0.902), and both negatively correlated with a composite AD biomarker (tau/amyloid beta 1‐42; TICS:r= −0.372;P= 0.001; T‐MoCA:r= −0.480;P< 0.001).DiscussionTICS and T‐MoCA are effective for remotely detecting cognitive impairment associated with AD in older adults. Strong correlation between tests provides construct validity for the newer T‐MoCA.HighlightsConstruct validity for the telephone adaptation of the Montreal Cognitive Assessment (T‐MoCA) was newly established against the Telephone Interview for Cognitive Status (TICS).TICS and T‐MoCA effectively detected cognitive impairment with remote administration.Both tests negatively correlated with a composite cerebrospinal fluid Alzheimer's disease (AD) biomarker (tau/amyloid beta 1‐42).