Synthesis and antiviral evaluation of some novel tricyclic pyrazolo[3,4-b]indole nucleosides.
Synthesis and antiviral evaluation of some novel tricyclic pyrazolo[3,4-b]indole nucleosides.
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一些新型三环吡唑并[3,4-b]吲哚核苷的合成和抗病毒评价。
DOI：
10.1081/ncn-120039253
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Townsend,LeroyB
中科院分区：
文献类型：
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作者：
Williams,JohnD;Drach,JohnC;Townsend,LeroyB
以3-甲酰基-2-氯吲哚和3-氰基-2-氯吲哚核苷为原料，用肼反应合成了新型的吡唑并[3，4-b]吲哚核苷类似物。文献中很少有吡唑并[3，4-b]吲哚杂环的例子，这是首次合成含有该杂环的核苷类似物。这些新的吡唑并[3，4-b]吲哚核苷对人巨细胞病毒和单纯疱疹病毒1型有活性，但这种活性与细胞毒性没有很好的分离。
Novel pyrazolo[3,4‐b]indole nucleoside analogs were synthesized from the corresponding 3‐formyl‐2‐chloroindole and 3‐cyano‐2‐chloroindole nucleosides by treatment with hydrazine. Very few examples of pyrazolo[3,4‐b]indole heterocycles have been published in the literature and this is the first synthesis of nucleoside analogs containing this heterocycle. These new pyrazolo[3,4‐b]indole nucleosides were active against human cytomegalovirus and herpes simplex virus type 1, but this activity was not well separated from cytotoxicity.