Enzyme inhibitors of microbial origin.
Enzyme inhibitors of microbial origin.
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微生物来源的酶抑制剂。
DOI：
10.1098/rstb.1980.0095
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
P. Schindler
中科院分区：
文献类型：
--
作者：
P. Schindler
过去几十年来，微生物来源的酶抑制剂的筛选一直是寻找作为治疗剂或抗生素剂具有潜在重要性的新代谢物的繁荣领域。本综述试图对此类筛查的最新成就进行调查。特别重点关注工业重点发展领域的酶抑制剂和筛选系统。其中包括关于检测可逆和不可逆 β-内酰胺酶抑制剂的改进方法的一些注释，以及从猪胰腺中分离出的链霉菌菌株中提出的独特的 α-淀粉酶抑制剂。该抑制剂 (HOE 467) 可能具有治疗糖尿病、肥胖症和肥胖症的潜在用途。结果表明，从微生物中筛选酶抑制剂仍然是未来研究的核心挑战之一。
The screening for enzyme inhibitors of microbial origin in the past decades has been a prosperous area to find new metabolites that are of potential importance as therapeutic or antibiotic agents. This review attempts a survey of recent achievements in this type of screening. Special emphasis is given to enzyme inhibitors and screening systems in fields where industry has a main interest in development. This includes some notes on the improved methodology for the detection of reversible and irreversible inhibitors of beta-lactamases and the presentation of a unique inhibitor of alpha-amylase from porcine pancreas isolated from a strain of Streptomyces tendae. This inhibitor (HOE 467) may be of potential use in the treatment of diabetic conditions, obesity and adipositas. The results show that the screening for enzyme inhibitors from microorganisms still provides one of the central challenges for future research.