Neurogenesis and neuronal circuit formation in the Drosophila visual center
Neurogenesis and neuronal circuit formation in the Drosophila visual center
复制标题
果蝇视觉中枢的神经发生和神经元回路形成
DOI：
10.1111/dgd.12151
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发表时间：
2014
影响因子：
2.5
通讯作者：
M.
中科院分区：
文献类型：
--
作者：
Suzuki;T. and Sato;M.
TheDrosophilaoptic lobe is composed of a wide variety of neurons that form laminar structures and columnar units. The fly optic lobe shares structural features with the mammalian brain, and fly genetics allow precise genetic manipulations. Thus, theDrosophilavisual center is an excellent model for studying the mechanisms underlying the establishment of a functional neuronal circuit during brain development. However, little is understood about the developmental mechanisms that produce neuronal diversity and establish neuronal circuits in the medulla, the largest component of the optic lobe. Our recent research revealed key features of medulla development, such as birth‐order‐dependent specification of neuronal types and the subdivision of the medulla primordium into concentric zones, which is characterized by the expression of four transcription factors. Here, we review recent investigations into the development of the medulla and discuss the mechanisms that establish functional neuronal circuits.
