Association of adiponectin with blood pressure in healthy people
Association of adiponectin with blood pressure in healthy people
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DOI：
10.1111/j.1365-2265.2012.04370.x
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发表时间：
2013-02-01
影响因子：
3.2
通讯作者：
Matsuzawa, Yuji
中科院分区：
文献类型：
--
作者：
Baden, Megu Y.;Yamada, Yuya;Matsuzawa, Yuji
目的随着肥胖相关疾病的日益流行，代谢综合征及其关键因子脂联素越来越受到人们的关注。据报道，低脂联血症是高血压的危险因素，并与内皮功能障碍有关，而内皮功能障碍与高血压等肥胖并发症密切相关。由于有关血压正常人群血清脂联素水平的信息有限，我们进行了大规模研究，以确定主要在血压正常人群中脂联素与血压 (BP) 的关系。设计、患者和测量 在 21 100 名无明显疾病的日本成年人（12 363 名男性和 8 737 名女性）中，我们通过问卷调查、体格测量和包括血清脂联素水平在内的实验室参数测量，研究了血清脂联素浓度与血压之间的关系。结果 正如已经报道的那样，患有低脂联血症的受试者具有较高的收缩压和舒张压。有趣的是，脂联素较高的受试者的收缩压和舒张压较低。根据线性回归分析，脂联素与收缩压和舒张压呈显着负相关，与其他变量无关。根据脂联素五分位数进行协方差分析表明，脂联素最高五分位数的收缩压和舒张压显着低于其他五分位数。结论 这项研究表明，不仅在高血压人群中，而且在血压正常人群中，脂联素较高时，收缩压和舒张压都有显着降低的趋势。
Objective With the increasing prevalence of diseases related to obesity, metabolic syndrome and its key player adiponectin are now attracting considerable attention. Hypoadiponectinaemia is reported to be a risk factor for hypertension and associated with endothelial dysfunction, which is closely related to complications of obesity such as hypertension. As there is limited information regarding serum adiponectin levels in normotensive people, we undertook the large-scale study to determine the association of adiponectin with blood pressure (BP) in mainly normotensive people. Design, patients and measurements In 21 100 Japanese adults (12 363 men and 8737 women) who had no apparent diseases, we examined the relationship between the serum adiponectin concentration and BP by performing a questionnaire survey, physical measurements and measurement of laboratory parameters including the serum adiponectin level. Results Subjects with hypoadiponectinaemia had higher systolic and diastolic BPs as already reported. And interestingly, subjects with higher adiponectin had lower systolic and diastolic BP. According to linear regression analysis, adiponectin showed a significant negative correlation with systolic and diastolic BP independently of the other variables. Analysis of covariance according to adiponectin quintiles showed that systolic and diastolic BP in highest adiponectin quintile was significantly lower than in other quintiles. Conclusions This study revealed that there were significant trends toward lower systolic and diastolic BP with higher adiponectin not only in hypertensive people but also in normotensive people.