Cerebral/Peripheral Vascular Reactivity and Neurocognition in Middle-Age Athletes.
Cerebral/Peripheral Vascular Reactivity and Neurocognition in Middle-Age Athletes.
复制标题
DOI：
10.1249/mss.0000000000000717
复制
发表时间：
2015-12
影响因子：
4.1
通讯作者：
Haley AP
中科院分区：
文献类型：
--
作者：
Tarumi T;Gonzales MM;Fallow B;Nualnim N;Lee J;Pyron M;Tanaka H;Haley AP
中年血管疾病风险与晚年认知障碍的发生率较高相关。有规律的有氧运动可以改善血管功能，这反过来又可以转化为更好的认知功能。本研究的目的是确定久坐和运动训练的中年人的心肺适能、脑和外周血管反应性和认知功能之间的关系。32名43 - 65岁的运动训练参与者和27名健康的久坐参与者接受了最大摄氧量（VO2max）、神经认知评估、脑血管对CO2的反应性（CVR）和肱动脉血流介导的扩张（FMD）的测量。年龄、性别、教育程度、空腹血糖和血压无组间差异。与久坐不动的受试者相比，经过耐力训练的运动员在记忆方面表现出更好的认知表现（z分数：− 0.36 ± 1.11 vs. 0.30 ± 0.76，P <0.01），注意力-执行功能（z评分：− 0.21 ± 0.53 vs. 0.18 ± 0.72，P = 0.02）和总认知综合评分（z评分：− 0.27 ± 0.63 vs. 0.23 ± 0.57，P <0.01）。此外，运动训练组的肱动脉FMD（4.70 ± 2.50% vs.7.13 ± 3.09%，P <0.01）和CVR（4.19 ± 0.71%/mmHg vs.4.69 ± 1.06%/mmHg，P = 0.052）高于久坐组。总认知综合评分与肱动脉FMD（r = 0.36，P <0.01）和CVR（r = 0.30，P = 0.03）呈显著正相关。最后，当肱FMD和CVR作为协变量输入时，总认知综合评分的健身相关组间差异显著减弱（均P> 0.05）。耐力训练的中年人表现出更好的认知能力，这可能至少部分是由他们增强的血管功能介导的，包括大脑和内皮依赖性血管反应性。
Midlife vascular disease risk is associated with higher incidence of cognitive impairment in late life. Regular aerobic exercise improves vascular function, which in turn may translate into better cognitive function. The purpose of this study was to determine the associations among cardiorespiratory fitness, cerebral and peripheral vascular reactivity, and cognitive function in the sedentary and endurance-trained middle-aged adults. Thirty-two endurance-trained and 27 healthy sedentary participants aged 43–65 years underwent measurements of maximal oxygen uptake (VO2max), neurocognitive assessment, cerebrovascular reactivity to CO2 (CVR), and brachial artery flow-mediated dilation (FMD). There were no group differences in age, sex, education level, fasting blood glucose, and blood pressure. Compared with sedentary subjects, endurance-trained athletes demonstrated better cognitive performance on memory (z-score: −0.36±1.11 vs. 0.30±0.76, P<0.01), attention-executive function (z-score: −0.21±0.53 vs. 0.18±0.72, P=0.02), and total cognitive composite scores (z-score: −0.27±0.63 vs. 0.23±0.57, P<0.01). Furthermore, brachial FMD (4.70±2.50 % vs. 7.13±3.09 %, P<0.01) and CVR (4.19±0.71 %/mmHg vs. 4.69±1.06 %/mmHg, P=0.052) were greater in endurance-trained individuals than in the sedentary subjects. Total cognitive composite scores showed a significant positive association with brachial FMD (r = 0.36, P < 0.01) and CVR (r = 0.30, P = 0.03). Finally, when brachial FMD and CVR were entered as covariates, fitness-related group differences in total cognitive composite score were significantly attenuated (all P>0.05). Endurance-trained middle-aged adults demonstrated better cognitive performance which may, at least in part, be mediated by their enhanced vascular function, including cerebral and endothelial-dependent vascular reactivity.