Ruptured cerebral artery aneurysm and bacterial meningitis in a man with osteogenesis imperfecta
Ruptured cerebral artery aneurysm and bacterial meningitis in a man with osteogenesis imperfecta
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DOI：
10.1097/01.paf.0000203150.95087.b6
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发表时间：
2006-06-01
影响因子：
1
通讯作者：
Nashelsky, MB
中科院分区：
文献类型：
--
作者：
Havlik, DM;Nashelsky, MB
这份报告描述了一名患有成骨不全症的 38 岁男性，他死于脑动脉瘤破裂和细菌性脑膜炎。他过去患有多处长骨骨折，在去世前约4个月，他接受了手术以缓解基底压痕症状。由于术后伤口感染，手术变得复杂。接下来的4个月里，他出现间歇性头痛和呕吐。他被发现死在家中的床上。尸检显示，他患有前交通动脉瘤破裂和细菌性脑膜炎。脑脊液和血培养有金黄色葡萄球菌生长。成骨不全症是一种 I 型胶原蛋白疾病。 I 型胶原蛋白存在于许多组织中，包括血管。脑动脉瘤形成的病因是多因素的。一些脑动脉瘤患者已显示出 III 型胶原蛋白异常。目前还没有关于 I 型胶原蛋白异常与动脉瘤之间关系的报道。脑膜炎也可能导致脑动脉瘤，但通常是由曲霉属或分枝杆菌属引起。我们报道的案例是独一无二的；脑动脉瘤的形成可能是由于成骨不全和/或细菌性脑膜炎造成的。
This report describes a 38-year-old man with osteogenesis imperfecta who died of a ruptured cerebral artery aneurysm and bacterial meningitis. He had multiple long bone fractures in the past and approximately 4 months before death, he had surgery to relieve symptoms of basilar impression. The surgery was complicated by a postoperative wound infection. For the next 4 months, he had intermittent headaches and vomiting. He was found dead in his bed at home. At autopsy, he had a ruptured anterior communicating artery aneurysm and bacterial meningitis. Cerebrospinal fluid and blood cultures had growth of Staphylococcus aureus. Osteogenesis imperfecta is a disorder of type I collagen. Type I collagen is present in many tissues, including blood vessels. The etiology of cerebral artery aneurysm formation is multifactorial. Some patients with cerebral artery aneurysms have been shown to have abnormalities in type III collagen. There has not been a reported relationship made between abnormalities in type I collagen and aneurysms. Meningitis can also result in cerebral artery aneurysms, but they are usually due to Aspergillus or Mycobacterium species. The case we report is unique; cerebral artery aneurysm formation may have been due to osteogenesis imperfecta and/or bacterial meningitis.