IL1B rs1143634 Polymorphism, Cigarette Smoking, Alcohol Use, and Lung Cancer Risk in a Japanese Population
IL1B rs1143634 Polymorphism, Cigarette Smoking, Alcohol Use, and Lung Cancer Risk in a Japanese Population
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DOI：
10.1097/jto.0b013e3181c8cae3
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发表时间：
2010-03-01
影响因子：
20.4
通讯作者：
Nakanishi, Yoichi
中科院分区：
文献类型：
--
作者：
Kiyohara, Chikako;Horiuchi, Takahiko;Nakanishi, Yoichi
背景：白细胞介素1B （IL1B）参与环境或职业性毒素引起的肺部炎症。慢性炎症与肺癌的发生有关。方法：我们在一项由462例肺癌患者和379例对照者组成的病例对照研究中评估了IL1B （rs1143634,3954c > T）的作用。采用Logistic回归评估调整后的优势比（OR）和95%置信区间（95% CI）。结果与讨论：有吸烟史且至少有一个T等位基因（校正后OR = 5.45, 95% CI = 2.75-4.42, p < 0.01）的人患肺癌的风险高于CC基因型（校正后OR = 2.86, 95% CI = 2.02-4.05, p < 0.01）的人（对照）。IL1B rs1143634基因型与吸烟之间相互作用的调整归因比例估计为0.45 (95% CI = 0.08-0.83, p = 0.02)，表明至少有一个T等位基因的吸烟者中45%的肺癌额外风险是由于加性相互作用。饮酒过量且至少有一个T等位基因的受试者与饮酒适量和CC基因型的饮酒者相比，风险显著增加（OR = 2.48, 95% CI = 1.36-4.54, p < 0.01）。多态性与酒精摄入量之间没有相互作用。结论：我们的研究结果表明，IL1B rs1143634多态性的T等位基因携带者可能与肺癌的高风险有关，特别是在吸烟者中。本研究中提出的IL1B rs1143634与吸烟的相互作用需要进一步的研究来证实。
Background: Interleukin 1B (IL1B) is involved in pulmonary inflammation induced by environmental or occupational toxins. Chronic inflammation has been implicated in the development of lung cancer.Methods: We evaluated the role of IL1B (rs1143634, 3954C > T) in a case-control study comprised of 462 lung cancer cases and 379 controls in a Japanese population. Logistic regression was used to assess the adjusted odds ratios (OR) and 95% confidence intervals (95% CI).Results and Discussion: Individuals with a history of smoking and at least one T allele (adjusted OR = 5.45, 95% CI = 2.75-4.42, p < 0.01) presented a higher risk of lung cancer than those with the CC genotype (adjusted OR = 2.86, 95% CI = 2.02-4.05, p < 0.01) as compared with never smokers with the CC genotype (reference). The adjusted attributable proportion because of interaction between the IL1B rs1143634 genotypes and smoking was estimated to be 0.45 (95% CI = 0.08-0.83, p = 0.02), indicating that 45% of the excess risk for lung cancer in ever smokers with at least one T allele was due to additive interaction. Subjects with excessive alcohol intake and at least one T allele had a significantly higher risk (OR = 2.48, 95% CI = 1.36-4.54, p < 0.01) than drinkers with appropriate intake and the CC genotype. There was no interaction between the polymorphism and alcohol intake.Conclusions: Our findings indicate the possible association of the T allele carriers of the IL1B rs1143634 polymorphism with higher risk of lung cancer especially among smokers. Additional studies are warranted to confirm the IL1B rs1143634-smoking interaction suggested in this study.