Effect of Interaction Between Slow Wave Sleep and Obstructive Sleep Apnea on Insulin Resistance: A Large-Scale Study.
Effect of Interaction Between Slow Wave Sleep and Obstructive Sleep Apnea on Insulin Resistance: A Large-Scale Study.
复制标题
慢波睡眠和阻塞性睡眠呼吸暂停之间的相互作用对胰岛素抵抗的影响：一项大规模研究
DOI：
10.2147/nss.s311130
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发表时间：
2021
影响因子：
3.4
通讯作者：
Yin S
中科院分区：
文献类型：
--
作者：
Huang W;Liu Y;Wang X;Li X;Liu Y;Zou J;Xu H;Zhu H;Yi H;Guan J;Yin S
目的慢波睡眠（SWS）和阻塞性睡眠呼吸暂停（OSA）是近年来研究的热点。然而，它们对胰岛素抵抗（IR）的联合作用仍不清楚。本研究探讨了SWS是否影响OSA和IR. Methods之间的关系，我们招募了潜在的参与者在我们的睡眠中心从2007年到2019年。我们收集了人口统计学和临床特征，并确定IR状态。SWS来自多导睡眠图数据。结果共纳入6966例受试者，其中OSA组5709例，原发性打鼾组1257例。SWS减少会增加OSA患者的IR风险，但不会增加PS患者的IR风险。OSA患者合并SWS <6.5% were more likely to have IR than were those with SWS >21.3%。在调整潜在的混杂因素后，OSA是IR的独立危险因素。在根据SWS百分比的分层分析中，调整潜在混杂因素后，SWS <6.5%的OSA患者与PS组相比，IR的比值比为2.461（95%CI，2.018-3.002）。结论OSA患者SWS越少，IR发生的可能性越大，而PS患者SWS越少，IR发生的可能性越大。OSA与IR独立相关，另外，OSA合并SWS极度缺乏对IR状态的影响比OSA本身更有害。
Objective Slow-wave sleep (SWS) and obstructive sleep apnea (OSA) have attracted recent research attention. However, their joint effects on insulin resistance (IR) remain unclear. This study explored whether SWS influences the relationship between OSA and IR. Methods We enrolled potential participants in our sleep center from 2007 to 2019. We collected demographic and clinical characteristics and determined IR status. SWS was derived from polysomnography data. Logistic regression analysis was used to reveal the associations between SWS and IR. Results In all, 6966 participants (5709 OSA and 1257 primary snoring [PS] subjects) were enrolled. Less SWS increased the risk of IR in OSA patients but not in PS patients. OSA patients with SWS <6.5% were more likely to have IR than were those with SWS >21.3%. OSA was an independent risk factor for IR after adjusting for potential confounding factors. In stratified analyses according to the percentage of SWS, OSA patients with SWS <6.5% had an odds ratio for IR of 2.461 (95% CI, 2.018–3.002) compared to the PS group after adjusting for potential confounders. Conclusion Less SWS is associated with higher odds for IR in OSA patients but not in PS patients. OSA is independently associated with IR. In addition, OSA combined with an extreme lack of SWS has a more harmful effect on the status of IR than OSA itself.