Perigenual anterior cingulate morphology covaries with perceived social standing.
Perigenual anterior cingulate morphology covaries with perceived social standing.
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DOI：
10.1093/scan/nsm013
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发表时间：
2007-09
影响因子：
4.2
通讯作者：
Hariri, Ahmad R
中科院分区：
文献类型：
--
作者：
Gianaros, Peter J;Horenstein, Jeffrey A;Cohen, Sheldon;Matthews, Karen A;Brown, Sarah M;Flory, Janine D;Critchley, Hugo D;Manuck, Stephen B;Hariri, Ahmad R
低社会经济地位（SES）会增加患精神疾病和慢性疾病的风险。低社会经济地位可能影响身心健康的一个与压力相关的途径是通过认为社会地位低下（称为低主观社会地位）。该提议暗示，介导压力反应和社会情绪行为的重叠大脑区域作为神经解剖学基础，可以合理地将主观社会地位与健康相关结果联系起来。在对该提案的测试中，我们在健康社区样本中使用了计算结构神经成像方法（基于体素的形态测量）来检查主观社会地位报告与区域灰质体积之间的关系。结果显示，在考虑了潜在的人口统计学混杂因素、亚临床抑郁症状、消极情绪的倾向形式和SES的传统指标后，低主观社会地位的自我报告与前扣带皮层（pACC）膝周区灰质体积的减少呈独特的共变性，pACC是一个参与体验情绪和调节对社会心理压力的行为和生理反应的大脑区域。 pACC 可能代表一种神经解剖学基础，通过它感知的社会地位与心理和身体健康相关。
Low socioeconomic status (SES) increases the risk for developing psychiatric and chronic medical disorders. A stress-related pathway by which low SES may affect mental and physical health is through the perception of holding a low social standing, termed low subjective social status. This proposal implicates overlapping brain regions mediating stress reactivity and socioemotional behaviors as neuroanatomical substrates that could plausibly link subjective social status to health-related outcomes. In a test of this proposal, we used a computational structural neuroimaging method (voxel-based morphometry) in a healthy community sample to examine the relationships between reports of subjective social status and regional gray matter volume. Results showed that after accounting for potential demographic confounds, subclinical depressive symptoms, dispositional forms of negative emotionality and conventional indicators of SES, self-reports of low subjective social status uniquely covaried with reduced gray matter volume in the perigenual area of the anterior cingulate cortex (pACC)—a brain region involved in experiencing emotions and regulating behavioral and physiological reactivity to psychosocial stress. The pACC may represent a neuroanatomical substrate by which perceived social standing relates to mental and physical health.