Fourfold faster rate of genome rearrangement in nematodes than in Drosophila
Fourfold faster rate of genome rearrangement in nematodes than in Drosophila
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DOI：
10.1101/gr.172702
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发表时间：
2002-06-01
期刊：
影响因子：
7
通讯作者：
Wolfe, KH
中科院分区：
文献类型：
--
作者：
Coghlan, A;Wolfe, KH
我们将秀丽隐杆线虫的基因组与布氏秀丽隐杆线虫13%的基因组进行了比较，在它们的染色体上确定了252个保守区段。我们检测到517个染色体重排，易位、倒位和转座的比例约为1∶1∶2。我们估计这两个物种在5000万到1.2亿年前分化，并且从那时起它们的整个基因组之间发生了4030次重排。我们对重排率的估计为每百万年每兆碱基0.4 - 1.0次染色体断裂，这至少是果蝇的四倍，此前果蝇被报道在真核生物中重排率是最快的。易位的断点与秀丽隐杆线虫基因组中的分散重复序列和基因家族成员密切相关。
We compared the genome of the nematode Caenorhabditis elegans to 13% of that of Caenorhabditis briggsae, identifying 252 conserved segments along their chromosomes. We detected 517 chromosomal rearrangements, with the ratio of translocations to inversions to transpositions being similar to1:1:2. We estimate that the species diverged 50-120 million years ago, and that since then there have been 4030 rearrangements between their whole genomes. Our estimate of the rearrangement rate, 0.4-1.0 chromosomal breakages/Mb per Myr, is at least four times that of Drosophila, which was previously reported to be the fastest rate among eukaryotes. The breakpoints of translocations are strongly associated with dispersed repeats and gene family members in the C elegans genome.