Thermosensitive liposomes entrapping iron oxide nanoparticles for controllable drug release
Thermosensitive liposomes entrapping iron oxide nanoparticles for controllable drug release
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DOI：
10.1088/0957-4484/20/13/135101
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发表时间：
2009-04-01
期刊：
影响因子：
3.5
通讯作者：
Yang, Chung-Shi
中科院分区：
文献类型：
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作者：
Tai, Lin-Ai;Tsai, Pi-Ju;Yang, Chung-Shi
氧化铁纳米颗粒可以作为一个加热源，在交变磁场（AMF）暴露。氧化铁纳米颗粒可以与热敏纳米载体混合，用于高温诱导的药物释放，但这种设计和机制可能不适合组织容易受到环境温度变化（例如脑组织）影响的可控药物释放应用。在本研究中，氧化铁纳米粒包埋在热敏脂质体内的AMF诱导药物释放，而环境温度保持在一个恒定的水平。将羧基荧光素与氧化铁纳米颗粒共包埋在脂质体中作为监测药物释放的模型化合物，并用水循环器夹套保持环境温度。这些实验已在溶液、体模和麻醉动物中成功进行。此外，将热敏脂质体注入大鼠前臂骨骼肌，并通过植入的微透析灌注探针与在线激光诱导荧光检测器监测由外部交变磁场触发的羧基荧光素的释放。在未来，这种设备可以应用于同时磁共振成像和非侵入性药物释放在温度敏感的应用。
Iron oxide nanoparticles can serve as a heating source upon alternative magnetic field (AMF) exposure. Iron oxide nanoparticles can be mixed with thermosensitive nanovehicles for hyperthermia-induced drug release, yet such a design and mechanism may not be suitable for controllable drug release applications in which the tissues are susceptible to environmental temperature change such as brain tissue. In the present study, iron oxide nanoparticles were entrapped inside of thermosensitive liposomes for AMF-induced drug release while the environmental temperature was maintained at a constant level. Carboxyfluorescein was co-entrapped with the iron oxide nanoparticles in the liposomes as a model compound for monitoring drug release and environmental temperature was maintained with a water circulator jacket. These experiments have been successfully performed in solution, in phantom and in anesthetized animals. Furthermore, the thermosensitive liposomes were administered into rat forearm skeletal muscle, and the release of carboxylfluorescein triggered by the external alternative magnetic field was monitored by an implanted microdialysis perfusion probe with an on-line laser-induced fluorescence detector. In the future such a device could be applied to simultaneous magnetic resonance imaging and non-invasive drug release in temperature-sensitive applications.