Massive allografts in tumour surgery
Massive allografts in tumour surgery
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DOI：
10.1007/s00264-006-0223-7
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发表时间：
2006-12-01
影响因子：
2.7
通讯作者：
Kofranek, I.
中科院分区：
文献类型：
--
作者：
Matejovsky, Z., Jr.;Matejovsky, Z.;Kofranek, I.
我们提供了我们在肿瘤切除后使用大量同种异体骨移植的个人经验。我们展示了1961-1990年间71例患者(72例同种异体移植)的远期结果。骨关节移植物和间质移植物的长期存活率约为60%。移植物的骨折在大多数情况下是可以挽救的。在几乎所有病例中，感染都会导致移植物被移除。对影响移植物存活、改建及并发症的因素进行了讨论。移植物的冷冻保存、固定和负载制度会影响这些因素，移植物-宿主交界处周围使用自体骨片以及化疗或放疗的应用也会影响这些因素。移植物的骨折在大多数情况下是可以挽救的，而感染仍然是最严重的并发症，随时可能发生。即使随着肿瘤内假体的改进，使用同种异体移植仍然是一种选择，特别是在年轻患者中。
We offer our personal experience of the use of massive bone allografts after tumour resection. We demonstrate the long-term results from 71 patients ( 72 allografts) operated on between 1961 and 1990. The long-term survival rate in osteoarticular and intercalary grafts is around 60%. Fractures of the graft can be salvaged in most cases. Infection leads to the removal of the graft in almost all cases. Factors influencing the survival, remodelling and complications of the grafts are discussed. The regime of cryopreservation, fixation and loading of the graft influence these factors, as do the use of autologous bone chips around the allograft-host junction and the application of chemotherapy or radiation. Fracture of the graft can be salvaged in most cases, as opposed to infection which remains the most severe complication and can occur at any time. Even with the improvement of tumour endoprostheses, the use of allografts remains an option, especially in young patients.