A biocompatible approach to surface modification: Biodegradable polymer functionalized super-paramagnetic iron oxide nanoparticles
A biocompatible approach to surface modification: Biodegradable polymer functionalized super-paramagnetic iron oxide nanoparticles
复制标题
生物相容性表面改性方法：可生物降解聚合物功能化超顺磁性氧化铁纳米颗粒
DOI：
10.1016/j.msec.2010.02.009
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发表时间：
2010-05-10
影响因子：
7.9
通讯作者：
Zhou, Shaobing
中科院分区：
文献类型：
--
作者：
Sun, Lin;Huang, Chi;Zhou, Shaobing
本研究首先采用改良的受控化学共沉淀法，从亚铁/三价铁混合盐溶液的碱性介质中制备出尺寸范围为10-20 nm的Fe3O4纳米粒子。然后，通过聚乙二醇（PEG）和聚（乙二醇）-共聚（d，l-丙交酯）（PELA）等可生物降解聚合物对超顺磁性氧化铁纳米颗粒进行共价修饰。纳米颗粒的尺寸及其分布通过动态光散射测量（DLS）来确定。通过X射线粉末衍射（XRD）、透射电子显微镜（TEM）、电子衍射（ED）、傅里叶变换红外光谱（FT-IR）和紫外-可见分光光度法（UV）对磁性纳米粒子进行了表征。使用振动样品磁力计测量磁性。并进行5-二甲基噻唑-2-基-2,5-二苯基溴化四唑（MTT）测定来评估磁性纳米颗粒的生物相容性。结果表明，PEG和PELA功能化的Fe3O4纳米粒子的平均尺寸分别为43.2和79.3 nm，并表现出优异的生物相容性。 (C) 2010 Elsevier B.V. 保留所有权利。
In the study, Fe3O4 nanoparticles with a size range of 10-20 nm were firstly prepared by the modified controlled chemical coprecipitation method from the solution of ferrous/ferric mixed salt-solution in alkaline medium. Then, the super-paramagnetic iron oxide nanoparticles were covalently modified by biodegradable polymers such as polyethylene glycol (PEG) and poly(ethylene glycol)-co-poly(d,l-lactide) (PELA). The size and its distribution of the nanoparticles were determined by dynamic light scattering measurements (DLS). The magnetic nanoparticles was characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), electron diffraction (ED), Fourier transform infrared spectroscopy (FT-IR) and UV-visible spectrophotometry (UV). Magnetic properties were measured using a vibrating sample magnetometer. And the 5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT) assay was performed to evaluate the biocompatibility of the magnetic nanoparticles. The results showed that the Fe3O4 nanoparticles functionalized by PEG and PELA possessed a mean size of 43.2 and 79.3 nm, respectively, and exhibited an excellent biocompatibility. (C) 2010 Elsevier B.V. All rights reserved.