Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system.
Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system.
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DOI：
10.1016/j.yhbeh.2013.02.017
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发表时间：
2013-05
影响因子：
3.5
通讯作者：
Bilbo, Staci D.
中科院分区：
文献类型：
--
作者：
Bilbo, Staci D.
许多神经精神疾病与免疫系统的严重失调有关，其中一些疾病的病因学也很引人注目。我们最近使用新生儿大肠杆菌感染的啮齿动物模型获得的证据揭示了对成年认知缺陷潜在机制的新见解，并表明个体的早期免疫史可能对于了解人类晚年发生精神健康障碍的相对风险至关重要。一次新生儿感染会在啮齿类动物的一生中对大脑内称为小胶质细胞的免疫细胞的功能进行编程，从而导致成年免疫挑战导致大脑内细胞因子的过度产生和相关的认知缺陷。我描述了免疫系统（尤其是小胶质细胞）在大脑发育过程中的重要作用，并讨论了早期大脑发育过程中免疫激活可以影响神经功能、免疫功能和认知的后期结果的多种方式。
Many neuropsychiatric disorders are associated with a strong dysregulation of the immune system, and several have a striking etiology in development as well. Our recent evidence using a rodent model of neonatal E. coli infection has revealed novel insight into the mechanisms underlying cognitive deficits in adulthood, and suggests that the early-life immune history of an individual may be critical to understanding the relative risk of developing later-life mental health disorders in humans. A single neonatal infection programs the function of immune cells within the brain, called microglia, for the life of the rodent such that an adult immune challenge results in exaggerated cytokine production within the brain and associated cognitive deficits. I describe the important role of the immune system, notably microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition.
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影响因子：
4.8
作者：
Chen, Hui;Simar, David;Morris, Margaret J.
通讯作者：
Morris, Margaret J.
影响因子：
2.7
作者：
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5.3
作者：
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作者：
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作者：
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