Regional and temporal variation in the incidence of multiple sclerosis in Finland 1979-1993
Regional and temporal variation in the incidence of multiple sclerosis in Finland 1979-1993
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DOI：
10.1159/000026241
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发表时间：
2000-03-01
影响因子：
5.7
通讯作者：
Hakama, M
中科院分区：
文献类型：
--
作者：
Sumelahti, ML;Tienari, PJ;Hakama, M
从20世纪60年代开始在芬兰进行的调查记录了多发性硬化症（MS）的不均匀地理分布，在本研究中，研究了1979-1993年期间在西部瓦萨和成之木地区以及南部乌乌西马的MS发病率。西部和南部地区的总体差异持续存在;西部地区每10万人中有8.7人，南部地区每10万人中有5.1人，成之木每10万人中有11.6人的发病率是邻近的瓦萨每10万人中有5.2人的两倍多，在成之木，男性的发病率呈上升趋势，在瓦萨，男女发病率均呈下降趋势，而在乌乌西马，男女发病率保持稳定。不同的发病率趋势不能很容易地解释的情况下确定的差异，但表明环境因素的影响，调制MS的发病率在15年的研究期间。版权所有（C）2000 S. Karger AG，巴塞尔。
Previous surveys in Finland from the 1960s have documented an uneven geographic distribution of multiple sclerosis (MS), In the present study, the incidence of MS was studied during 1979-1993 in the western Vaasa and Seinajoki regions and in southern Uusimaa. The overall difference between the western and southern regions persisted; 8.7 per 100,000 in the western, and 5.1 per 100,000 in the southern region, The incidence of 11.6 per 100,000 in Seinajoki was more than twofold greater than the 5.2 per 100,000 incidence found in neighboring Vaasa, An increasing incidence trend was observed for men in Seinajoki, and a decrease for both sexes in Vaasa, while in Uusimaa the incidence remained stable for both sexes. The different incidence trends could not be readily explained by differences in case ascertainment but suggest the effect of environmental factors that have modulated the incidence of MS during the 15-year study period. Copyright (C) 2000 S. Karger AG, Basel.