Attention and Working Memory Abilities in Children Treated for Acute Lymphoblastic Leukemia
Attention and Working Memory Abilities in Children Treated for Acute Lymphoblastic Leukemia
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DOI：
10.1002/cncr.25343
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发表时间：
2010-10-01
期刊：
影响因子：
6.2
通讯作者：
Conklin, Heather M.
中科院分区：
文献类型：
--
作者：
Ashford, Jason;Schoffstall, Corrie;Conklin, Heather M.
背景技术背景：为了将研究扩展到文献中流行的整体认知测量之外，本研究检查了儿童急性淋巴细胞白血病（ALL）幸存者的注意力和工作记忆（WM）能力，注意力和WM对智商（IQ）的单独贡献，以及它们与神经影像学变化的关系。方法：97例ALL患儿根据临床和生物学因素接受风险导向治疗。在巩固治疗期间，低风险患者接受了标准风险/高风险患者接受的一半剂量的静脉注射甲氨蝶呤，以及更少剂量的三联鞘内治疗。患者根据巩固磁共振成像扫描结束（正常或白质脑病）进行分类，并计算白色结构的连续测量值。作为方案研究的一部分，儿童在2年后（完成治疗）完成认知评估，使用数字广度向前（DSF）进行注意力评估，数字广度向后（DSB）进行WM评估。结果：总样本和标准/高危组的总数字跨度（TDS）、DSF和DSB相对于正常人受损（P
BACKGROUND: To extend investigation beyond global cognitive measures prevalent in the literature, this study examined attention and working memory (WM) abilities of survivors of childhood acute lymphoblastic leukemia (ALL), the separate contributions of attention and WM to intelligence quotient (IQ), and their association with neuroimaging changes. METHODS: Ninety-seven children with ALL received risk-directed therapy based on presenting clinical and biological factors. During consolidation therapy, low-risk patients received half the dose of intravenous methotrexate that standard-risk/high-risk patients received, and fewer doses of triple intrathecal therapy. Patients were classified according to end of consolidation magnetic resonance imaging scans (normal or leukoencephalopathy), and continuous measures of white matter structure were computed. As part of the protocol study, children completed cognitive assessment 2 years later (completion of therapy), using Digit Span Forward (DSF) for attention and Digit Span Backward (DSB) for WM. RESULTS: For the total sample and the standard-/high-risk group, Total Digit Span (TDS), DSF, and DSB were impaired relative to norms (P