Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression.
Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression.
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DOI：
10.4161/onci.1.2.18502
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发表时间：
2012-03-01
期刊：
影响因子：
7.2
通讯作者：
Kusmartsev S
中科院分区：
文献类型：
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作者：
Kusmartsev S
巨噬细胞浸润是大多数实体瘤的标志。我们的研究表明，浸润人肾细胞癌 (RCC) 的巨噬细胞显示 15-脂氧合酶-2 (15-LOX2) 的表达和活性显着增强。获得的数据表明，肿瘤相关巨噬细胞中脂氧合酶活性的增强会刺激癌症炎症并导致免疫功能障碍。
Macrophage infiltration is a hallmark in the majority of solid tumors. Our studies demonstrated that macrophages that infiltrate human renal cells carcinoma (RCC) display markedly enhanced expression and activity of 15-lipoxygenase-2 (15-LOX2). Obtained data suggest that enhanced lipoxygenase activity in tumor-associated macrophages stimulates cancer inflammation and causes immune dysfunction.