Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-α) levels in healthy men
Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-α) levels in healthy men
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DOI：
10.1016/j.cyto.2011.06.002
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发表时间：
2011-11-01
期刊：
影响因子：
3.8
通讯作者：
Gomez-Merino, D.
中科院分区：
文献类型：
--
作者：
Chennaoui, M.;Sauvet, F.;Gomez-Merino, D.
人类完全睡眠剥夺与白天嗜睡增加、运动能力下降、炎性细胞因子升高和激素/代谢紊乱有关。为了评估在持续和良好控制的条件下完全睡眠剥夺(TSD)40h对血浆中肿瘤坏死因子-α及其受体(TNFR1)、白介素6(IL-6)、皮质醇和C反应蛋白(CRP)水平、嗜睡和表现的影响，12名健康男性(29+/-3年)参加了为期5天的睡眠剥夺实验(两个对照夜晚，然后是一个晚上的失眠和一个恢复的夜晚)。在0800~2300时(即睡眠剥夺25h~40h之间)，在睡眠剥夺前(第2天：D2)和之后(第4天：D4)分别进行一系列的采血、多次睡眠潜伏期、主观嗜睡度和反应时测试。我们发现，急性睡眠剥夺(即睡眠剥夺34小时和37小时后)可引起肿瘤坏死因子-α的显著升高(P
Total sleep deprivation in humans is associated with increased daytime sleepiness, decreased performance, elevations in inflammatory cytokines, and hormonal/metabolic disturbances.To assess the effects of 40 h of total sleep deprivation (TSD) under constant and well controlled conditions, on plasma levels of TNF-alpha and its receptor (TNFR1), interleukin-6 (IL-6), cortisol and C-reactive protein (CRP), sleepiness and performance, 12 healthy men (29 +/- 3 years) participated in a 5-days sleep deprivation experiment (two control nights followed by a night of sleep loss and one recovery night). Between 0800 and 2300 (i.e. between 25 and-40 h of sleep deprivation), a serial of blood sampling, multiple sleep latency, subjective levels of sleepiness and reaction time tests were completed before (day 2: D2) and after (day 4: D4) one night of sleep loss. We showed that an acute sleep deprivation (i.e. after 34 and 37 h of sleep deprivation) induced a significant increase in TNF-alpha (P