Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications
Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications
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DOI：
10.1016/j.mtcomm.2017.07.007
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发表时间：
2017-09-01
影响因子：
3.8
通讯作者：
Xiao, Bo
中科院分区：
文献类型：
--
作者：
Gregg, Sharon T.;Yuan, Qingchun;Xiao, Bo
众所周知，一氧化氮是一种有效的血管扩张剂、抗菌剂和杀肿瘤剂，然而，以可控的方式靶向递送一氧化氮是具有挑战性的，但对于成功的治疗应用是必要的。近年来，基于材料结构中N-二醇二氮烯鎓盐、S-亚硝基硫醇和金属eNO配位键的形成，发展了一些新的方法。典型的递送材料包括纳米多孔材料（例如沸石和金属有机框架）、硅酸盐颗粒和含有胺和硫醇官能团的聚合物。这些材料具有提供可控剂量的生物活性NO气体以满足未来未满足的治疗需求的前景。本文综述了这些交付材料和相关的生物学评估。为了解决NO储存及其释放特性与临床需求的匹配问题，仍需要进一步改进现有的方法和设计新的NO供体。
It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal eNO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.