Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005
Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005
复制标题
DOI：
10.1001/jama.299.17.2056
复制
发表时间：
2008-05-07
影响因子：
120.7
通讯作者：
Schrag, Stephanie J.
中科院分区：
文献类型：
--
作者：
Phares, Christina R.;Lynfield, Ruth;Schrag, Stephanie J.
背景B群链球菌是新生儿发病的主要传染性原因，并在老年人中引起大量疾病。2002年修订了通过分娩时化学预防围产期疾病的准则。候选疫苗正在开发中。目的描述在不断发展的预防策略期间，可能受益于疫苗接种的人群和新生儿中的疾病趋势。在10个参与活动性细菌核心监测/新发感染项目网络的州进行基于人群的监测。主要结果测量年龄和种族，结果1999- 2005年共报告侵袭性B族链球菌病14573例，死亡1348例。出生至6天婴儿中侵袭性B族链球菌病的发病率从1999- 2001年的0.47/1000活产下降到2003- 2005年的0.34/1000活产（P
Context Group B streptococcus is a leading infectious cause of morbidity in newborns and causes substantial disease in elderly individuals. Guidelines for prevention of perinatal disease through intrapartum chemoprophylaxis were revised in 2002. Candidate vaccines are under development.Objective To describe disease trends among populations that might benefit from vaccination and among newborns during a period of evolving prevention strategies.Design and Setting Analysis of active, population- based surveillance in 10 states participating in the Active Bacterial Core surveillance/ Emerging Infections Program Network.Main Outcome Measures Age- and race- specific incidence of invasive group B streptococcal disease.Results There were 14 573 cases of invasive group B streptococcal disease during 1999- 2005, including 1348 deaths. The incidence of invasive group B streptococcal disease among infants from birth through 6 days decreased from 0.47 per 1000 live births in 1999- 2001 to 0.34 per 1000 live births in 2003- 2005 ( P