Helicobacter pylori is Associated with Less Fistulizing, Stricturing, and Active Colitis in Crohn's Disease Patients
Helicobacter pylori is Associated with Less Fistulizing, Stricturing, and Active Colitis in Crohn's Disease Patients
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DOI：
10.7759/cureus.6226
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发表时间：
2019-11-25
影响因子：
1.2
通讯作者：
De Melo, Silvio W., Jr.
中科院分区：
文献类型：
--
作者：
Fialho, Andre;Fialho, Andrea;De Melo, Silvio W., Jr.
前言幽门螺杆菌（HP）感染对克罗恩病（CD）的发展具有潜在的保护作用。缺乏评估HP与CD表型相关性的研究。本研究的目的是调查的临床特征和疾病活动性的CD患者被诊断为HP infection.MethodsThe图表的306例连续患者从炎症性肠病（IBD）数据库在佛罗里达大学医学院，杰克逊维尔从2014年1月至2016年7月进行了审查。91 CD患者进行HP测试，并在这些患者的监测活检狭窄，瘘管，结肠炎的频率进行了评估。ResultsOf 91 CD患者HP测试，19 HP感染。共有44名患者患有瘘管化/狭窄疾病，62名患者患有活动性结肠炎。在单变量分析中，HP感染患者的瘘管形成/狭窄疾病较少（21.1% vs. 55.6%，p = 0.009），活动性结肠炎较少（42.1% vs. 77.1%，p = 0.005）。在多因素分析中，HP感染仍然是瘘管/狭窄疾病表型的保护因素（OR：0.22; 95%CI：0.06-0.97; p = 0.022）和活动性结肠炎（OR：0.186; 95% CI：0.05-0.65;结论HP感染与CD患者的瘘管形成/狭窄程度和活动性结肠炎程度独立相关。我们的研究表明，有HP感染史的CD患者并发症的发生率较低。
IntroductionA potential protective role of Helicobacter pylori (HP) infection against the development of Crohn's disease (CD) has been postulated. There is a lack of studies evaluating the association of HP with CD phenotypes. The aim of this study was to investigate the clinical features and disease activity of patients with CD who were diagnosed with HP infection.MethodsThe charts of 306 consecutive patients from the inflammatory bowel disease (IBD) database at the University of Florida College of Medicine, Jacksonville from January 2014 to July 2016 were reviewed. Ninety-one CD patients who were tested for HP were included, and the frequencies of strictures, fistulas, and colitis in surveillance biopsies in these patients were evaluated.ResultsOf the 91 CD patients tested for HP, 19 had HP infection. A total of 44 patients had fistulizing/stricturing disease, and 62 patients had active colitis. In the univariate analysis, patients with HP infection had less fistulizing/stricturing disease (21.1% vs. 55.6%, p = 0.009) and less active colitis (42.1% vs. 77.1%, p = 0.005). In the multivariate analysis, HP infection remained as a protective factor for fistulizing/stricturing disease phenotype (OR: 0.22; 95%CI: 0.06-0.97; p = 0.022) and active colitis (OR: 0.186; 95% CI: 0.05-0.65; p = 0.010).ConclusionHP infection was independently associated with less fistulizing/stricturing disease and less active colitis in CD patients. Our study suggests CD patients with a history of HP infection are less prone to complications.